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Gene Review

MYRIP  -  myosin VIIA and Rab interacting protein

Homo sapiens

Synonyms: DKFZp586F1018, Exophilin-8, MyRIP, Myosin-VIIa-and Rab-interacting protein, Rab effector MyRIP, ...
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High impact information on MYRIP

  • Screening for potential effectors of the GTPase revealed that the Rab27a-binding protein Slac2c/MyRIP is associated with secretory granules of beta-cells [1].
  • In contrast, overexpression of the actin-binding domain of Slac2c/MyRIP led to a potent inhibition of exocytosis without detectable alteration in granule distribution [1].
  • Taken together our data suggest that Rab27a and Slac2c/MyRIP are part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton and participate to the regulation of the final steps of insulin exocytosis [1].
  • Attenuation of Slac2c/MyRIP expression by RNA interference did not modify basal secretion but severely impaired hormone release in response to secretagogues [1].
  • In transfected PC12 cells, overexpression of MyRIP was shown to interfere with the myosin VIIa tail localization [2].

Anatomical context of MYRIP


  1. Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Waselle, L., Coppola, T., Fukuda, M., Iezzi, M., El-Amraoui, A., Petit, C., Regazzi, R. Mol. Biol. Cell (2003) [Pubmed]
  2. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. El-Amraoui, A., Schonn, J.S., Küssel-Andermann, P., Blanchard, S., Desnos, C., Henry, J.P., Wolfrum, U., Darchen, F., Petit, C. EMBO Rep. (2002) [Pubmed]
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