The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

MYRIP  -  myosin VIIA and Rab interacting protein

Homo sapiens

Synonyms: DKFZp586F1018, Exophilin-8, MyRIP, Myosin-VIIa-and Rab-interacting protein, Rab effector MyRIP, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on MYRIP

  • Screening for potential effectors of the GTPase revealed that the Rab27a-binding protein Slac2c/MyRIP is associated with secretory granules of beta-cells [1].
  • In contrast, overexpression of the actin-binding domain of Slac2c/MyRIP led to a potent inhibition of exocytosis without detectable alteration in granule distribution [1].
  • Taken together our data suggest that Rab27a and Slac2c/MyRIP are part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton and participate to the regulation of the final steps of insulin exocytosis [1].
  • Attenuation of Slac2c/MyRIP expression by RNA interference did not modify basal secretion but severely impaired hormone release in response to secretagogues [1].
  • In transfected PC12 cells, overexpression of MyRIP was shown to interfere with the myosin VIIa tail localization [2].
 

Anatomical context of MYRIP

References

  1. Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Waselle, L., Coppola, T., Fukuda, M., Iezzi, M., El-Amraoui, A., Petit, C., Regazzi, R. Mol. Biol. Cell (2003) [Pubmed]
  2. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. El-Amraoui, A., Schonn, J.S., Küssel-Andermann, P., Blanchard, S., Desnos, C., Henry, J.P., Wolfrum, U., Darchen, F., Petit, C. EMBO Rep. (2002) [Pubmed]
 
WikiGenes - Universities