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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Otos  -  otospiralin

Mus musculus

Synonyms: Ocp10, Organ of Corti 10 kDa protein, Otospiralin
 
 
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High impact information on Otos

  • We recently described a novel gene, Otos, which encodes otospiralin, a small protein of unknown function that is produced by the fibrocytes of the cochlea and vestibule [1].
  • Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin [1].
  • We report here the discovery of otospiralin, an inner ear-specific protein that is produced by fibrocytes from these regions, including the spiral ligament and spiral limbus in the cochlea and the maculae and semicircular canals in the vestibule [2].
  • Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness [2].
  • This demonstrates that otospiralin is essential for the survival of the neurosensory epithelium [2].
 

Analytical, diagnostic and therapeutic context of Otos

  • To evaluate its functional importance, we downregulated otospiralin by cochlear perfusion of antisense oligonucleotides in guinea pigs [2].

References

  1. Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. Delprat, B., Ruel, J., Guitton, M.J., Hamard, G., Lenoir, M., Pujol, R., Puel, J.L., Brabet, P., Hamel, C.P. Mol. Cell. Biol. (2005) [Pubmed]
  2. Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness. Delprat, B., Boulanger, A., Wang, J., Beaudoin, V., Guitton, M.J., Ventéo, S., Dechesne, C.J., Pujol, R., Lavigne-Rebillard, M., Puel, J.L., Hamel, C.P. J. Neurosci. (2002) [Pubmed]
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