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Gene Review

NAT9  -  N-acetyltransferase 9 (GCN5-related,...

Homo sapiens

Synonyms: DKFZP564C103, EBS, EBSP, Embryo brain-specific protein, N-acetyltransferase 9, ...
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Disease relevance of NAT9


High impact information on NAT9

  • Associated single-nucleotide polymorphisms (SNPs) in the proximal peak lie in or near SLC9A3R1 (also called EBP50 and NHERF1) and NAT9, a new member of the N-acetyltransferase family [1].
  • A disease-associated SNP lying between SLC9A3R1 and NAT9 leads to loss of RUNX1 binding [1].
  • Two peaks of association here contain the psoriasis candidate genes SLC9A3R (solute carrier family 9, isoform 3 regulatory factor), NAT9 (N-acetyltransferase superfamily), and RAPTOR (rapamycin (TOR)) [3].
  • Furthermore, decreased numbers of mature myeloid cells (defined by Mab NAT-9 II:3F-6F [NAT-9]) (P less than 0.001) were demonstrated in all French-American-British (FAB) subtypes except refractory anaemia with sideroblasts (RA-S) [4].
  • NAT-9 II:3F-6F did not bind to circulating monocytes, T and B cells, erythrocytes and a variety of different human cell culture lines [5].

Anatomical context of NAT9

  • A monoclonal antibody, designated NAT-9 II:3F-6F (IgM), was generated by hybridization of mouse myeloma cells with spleen cell from mice immunized with normal human bone marrow cells [5].

Analytical, diagnostic and therapeutic context of NAT9

  • Scanning electron microscopy and electron backscattered patterns, EBSP, have been employed to reveal both the grain structure and texture of 90% cold-rolled polycrystalline nickel after 1-hour anneals at a variety of temperatures [6].


  1. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003) [Pubmed]
  2. No association between atopic dermatitis and the SLC9A3R1-NAT9 RUNX1 binding site polymorphism in Japanese patients. Hosomi, N., Fukai, K., Oiso, N., Kato, A., Fukui, M., Ishii, M. Clin. Exp. Dermatol. (2005) [Pubmed]
  3. Investigation of the chromosome 17q25 PSORS2 locus in atopic dermatitis. Morar, N., Bowcock, A.M., Harper, J.I., Cookson, W.O., Moffatt, M.F. J. Invest. Dermatol. (2006) [Pubmed]
  4. Monoclonal antibody ratios in malignant myeloid diseases: diagnostic and prognostic use in myelodysplastic syndromes. Kristensen, J.S., Hokland, P. Br. J. Haematol. (1990) [Pubmed]
  5. A monoclonal antibody (NAT-9 II:3F-6F) that identifies a differentiation antigen on human myeloid cells. Andreasen, R.B., Killmann, S.A., Olsson, L. Leuk. Res. (1985) [Pubmed]
  6. An EBSP study of isothermally-annealed cold-rolled nickel. Baker, I., Li, J. Microsc. Res. Tech. (2004) [Pubmed]
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