Gene Review:
SLC9A3R1 - solute carrier family 9, subfamily A (NHE3...
Homo sapiens
Synonyms:
EBP50, Ezrin-radixin-moesin-binding phosphoprotein 50, NHERF, NHERF-1, NHERF1, ...
- A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003)
- NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer. Dai, J.L., Wang, L., Sahin, A.A., Broemeling, L.D., Schutte, M., Pan, Y. Oncogene (2004)
- Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. Fraenzer, J.T., Pan, H., Minimo, L., Smith, G.M., Knauer, D., Hung, G. Int. J. Oncol. (2003)
- No association between atopic dermatitis and the SLC9A3R1-NAT9 RUNX1 binding site polymorphism in Japanese patients. Hosomi, N., Fukai, K., Oiso, N., Kato, A., Fukui, M., Ishii, M. Clin. Exp. Dermatol. (2005)
- Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. Mahon, M.J., Segre, G.V. J. Biol. Chem. (2004)
- The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Cardone, R.A., Bellizzi, A., Busco, G., Weinman, E.J., Dell'Aquila, M.E., Casavola, V., Azzariti, A., Mangia, A., Paradiso, A., Reshkin, S.J. Mol. Biol. Cell (2007)
- Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Mahon, M.J., Donowitz, M., Yun, C.C., Segre, G.V. Nature (2002)
- ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Bretscher, A., Chambers, D., Nguyen, R., Reczek, D. Annu. Rev. Cell Dev. Biol. (2000)
- Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor. Webster, G., Leung, T., Karthikeyan, S., Birrane, G., Ladias, J.A. Acta Crystallogr. D Biol. Crystallogr. (2001)
- A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Hall, R.A., Ostedgaard, L.S., Premont, R.T., Blitzer, J.T., Rahman, N., Welsh, M.J., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. Huang, P., Steplock, D., Weinman, E.J., Hall, R.A., Ding, Z., Li, J., Wang, Y., Liu-Chen, L.Y. J. Biol. Chem. (2004)
- Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylation. Lau, A.G., Hall, R.A. Biochemistry (2001)
- Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. Mohler, P.J., Kreda, S.M., Boucher, R.C., Sudol, M., Stutts, M.J., Milgram, S.L. J. Cell Biol. (1999)
- The apical Na(+)/H(+) exchanger isoform NHE3 is regulated by the actin cytoskeleton. Kurashima, K., D'Souza, S., Szászi, K., Ramjeesingh, R., Orlowski, J., Grinstein, S. J. Biol. Chem. (1999)
- The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins. Gentzsch, M., Cui, L., Mengos, A., Chang, X.B., Chen, J.H., Riordan, J.R. J. Biol. Chem. (2003)
- Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Demoulin, J.B., Seo, J.K., Ekman, S., Grapengiesser, E., Hellman, U., Rönnstrand, L., Heldin, C.H. Biochem. J. (2003)
- Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). Rochdi, M.D., Watier, V., La Madeleine, C., Nakata, H., Kozasa, T., Parent, J.L. J. Biol. Chem. (2002)
- The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. Park, M., Ko, S.B., Choi, J.Y., Muallem, G., Thomas, P.J., Pushkin, A., Lee, M.S., Kim, J.Y., Lee, M.G., Muallem, S., Kurtz, I. J. Biol. Chem. (2002)
- Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. Murtazina, R., Kovbasnjuk, O., Zachos, N.C., Li, X., Chen, Y., Hubbard, A., Hogema, B.M., Steplock, D., Seidler, U., Hoque, K.M., Tse, C.M., De Jonge, H.R., Weinman, E.J., Donowitz, M. J. Biol. Chem. (2007)
- The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. Benharouga, M., Sharma, M., So, J., Haardt, M., Drzymala, L., Popov, M., Schwapach, B., Grinstein, S., Du, K., Lukacs, G.L. J. Biol. Chem. (2003)
- Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway. Taouil, K., Hinnrasky, J., Hologne, C., Corlieu, P., Klossek, J.M., Puchelle, E. J. Biol. Chem. (2003)
- Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Maudsley, S., Zamah, A.M., Rahman, N., Blitzer, J.T., Luttrell, L.M., Lefkowitz, R.J., Hall, R.A. Mol. Cell. Biol. (2000)
- The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule. Reczek, D., Bretscher, A. J. Biol. Chem. (1998)
- NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. Wang, B., Bisello, A., Yang, Y., Romero, G.G., Friedman, P.A. J. Biol. Chem. (2007)
- Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Voltz, J.W., Weinman, E.J., Shenolikar, S. Oncogene (2001)
- Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. Brdicková, N., Brdicka, T., Andera, L., Spicka, J., Angelisová, P., Milgram, S.L., Horejsí, V. FEBS Lett. (2001)
- cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Yun, C.H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C.M., Weinman, E.J., Donowitz, M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Tracking of Quantum Dot-labeled CFTR Shows Near Immobilization by C-Terminal PDZ Interactions. Haggie, P.M., Kim, J.K., Lukacs, G.L., Verkman, A.S. Mol. Biol. Cell (2006)
- Overexpression, purification, and characterization of PDZ domain proteins NHERF and E3KARP in Escherichia coli. Park, K.S., Jeong, M.S., Kim, J.H., Jang, S.B. Protein Expr. Purif. (2005)