Gene Review:
STAT5A - signal transducer and activator of...
Homo sapiens
Synonyms:
MGF, STAT5, Signal transducer and activator of transcription 5A
Tarone,
Feltus,
Grimley,
Chung,
Fujii,
Soucy,
Brindle,
Toyama,
Friedrich,
Dong,
Simard,
Sudarshan,
Melner,
Yamashita,
Calvi,
Handa,
Williams,
Fang,
Pegoraro,
Manning,
Brizzi,
Powell,
Mehta,
Sun,
O'Shea,
Ringelstein,
Garbarino,
Stögbauer,
Schuringa,
Zhou,
Richer,
Postert,
Morrone,
Galon,
Nakajima,
Gingras,
Defilippi,
Iwase,
Schaefer,
Rui,
Moore,
Tan,
Lange,
Rosso,
Chen,
Dorn,
Owen,
Ihle,
Rabkin,
Horwitz,
Dentelli,
Xu,
Ricketts,
Halfter,
- The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. Williams, C.C., Allison, J.G., Vidal, G.A., Burow, M.E., Beckman, B.S., Marrero, L., Jones, F.E. J. Cell Biol. (2004)
- Human immunodeficiency virus type 1 infection inhibits granulocyte-macrophage colony-stimulating factor-induced activation of STAT5A in human monocyte-derived macrophages. Warby, T.J., Crowe, S.M., Jaworowski, A. J. Virol. (2003)
- Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. Rui, H., Xu, J., Mehta, S., Fang, H., Williams, J., Dong, F., Grimley, P.M. J. Biol. Chem. (1998)
- Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Rabkin, R., Sun, D.F., Chen, Y., Tan, J., Schaefer, F. Pediatr. Nephrol. (2005)
- Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Harir, N., Pecquet, C., Kerenyi, M., Sonneck, K., Kovacic, B., Nyga, R., Brevet, M., Dhennin, I., Gouilleux-Gruart, V., Beug, H., Valent, P., Lassoued, K., Moriggl, R., Gouilleux, F. Blood (2007)
- Functional interactions between Stat5 and the glucocorticoid receptor. Stöcklin, E., Wissler, M., Gouilleux, F., Groner, B. Nature (1996)
- Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Simard, J., Ricketts, M.L., Gingras, S., Soucy, P., Feltus, F.A., Melner, M.H. Endocr. Rev. (2005)
- STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Welte, T., Leitenberg, D., Dittel, B.N., al-Ramadi, B.K., Xie, B., Chin, Y.E., Janeway, C.A., Bothwell, A.L., Bottomly, K., Fu, X.Y. Science (1999)
- Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Riggins, R.B., Thomas, K.S., Ta, H.Q., Wen, J., Davis, R.J., Schuh, N.R., Donelan, S.S., Owen, K.A., Gibson, M.A., Shupnik, M.A., Silva, C.M., Parsons, S.J., Clarke, R., Bouton, A.H. Cancer Res. (2006)
- Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity. Richer, J.K., Lange, C.A., Manning, N.G., Owen, G., Powell, R., Horwitz, K.B. J. Biol. Chem. (1998)
- Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. Yamashita, H., Iwase, H., Toyama, T., Fujii, Y. Oncogene (2003)
- Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Widschwendter, A., Tonko-Geymayer, S., Welte, T., Daxenbichler, G., Marth, C., Doppler, W. Clin. Cancer Res. (2002)
- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells. Joung, Y.H., Lim, E.J., Lee, M.Y., Park, J.H., Ye, S.K., Park, E.U., Kim, S.Y., Zhang, Z., Lee, K.J., Park, D.K., Park, T., Moon, W.K., Yang, Y.M. Exp. Mol. Med. (2005)
- {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation. Defilippi, P., Rosso, A., Dentelli, P., Calvi, C., Garbarino, G., Tarone, G., Pegoraro, L., Brizzi, M.F. J. Cell Biol. (2005)
- Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. Mahajan, S., Vassilev, A., Sun, N., Ozer, Z., Mao, C., Uckun, F.M. J. Biol. Chem. (2001)
- Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells. Moore, M.A., Dorn, D.C., Schuringa, J.J., Chung, K.Y., Morrone, G. Exp. Hematol. (2007)
- STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. de Groot, R.P., Raaijmakers, J.A., Lammers, J.W., Jove, R., Koenderman, L. Blood (1999)
- Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Rosen, R.L., Winestock, K.D., Chen, G., Liu, X., Hennighausen, L., Finbloom, D.S. Blood (1996)
- Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: evidence from the transgenic adenocarcinoma of the mouse prostate system. Kazansky, A.V., Spencer, D.M., Greenberg, N.M. Cancer Res. (2003)
- A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities. Boucheron, C., Dumon, S., Santos, S.C., Moriggl, R., Hennighausen, L., Gisselbrecht, S., Gouilleux, F. J. Biol. Chem. (1998)
- Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin. Ota, J., Kimura, F., Sato, K., Wakimoto, N., Nakamura, Y., Nagata, N., Suzu, S., Yamada, M., Shimamura, S., Motoyoshi, K. Biochem. Biophys. Res. Commun. (1998)
- Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Boer, A.K., Drayer, A.L., Rui, H., Vellenga, E. Blood (2002)
- Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. Carlesso, N., Frank, D.A., Griffin, J.D. J. Exp. Med. (1996)
- Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells. Halfter, H., Postert, C., Friedrich, M., Ringelstein, E.B., Stögbauer, F. Brain Res. Mol. Brain Res. (2000)
- Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. Nakajima, H., Brindle, P.K., Handa, M., Ihle, J.N. EMBO J. (2001)
- Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. Kolenko, V., Rayman, P., Roy, B., Cathcart, M.K., O'Shea, J., Tubbs, R., Rybicki, L., Bukowski, R., Finke, J. Blood (1999)
- Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. Gouilleux, F., Pallard, C., Dusanter-Fourt, I., Wakao, H., Haldosen, L.A., Norstedt, G., Levy, D., Groner, B. EMBO J. (1995)
- Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. Isaksen, D.E., Baumann, H., Trobridge, P.A., Farr, A.G., Levin, S.D., Ziegler, S.F. J. Immunol. (1999)
- Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b. Al-Shami, A., Mahanna, W., Naccache, P.H. J. Biol. Chem. (1998)
- Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. Bacon, C.M., Tortolani, P.J., Shimosaka, A., Rees, R.C., Longo, D.L., O'Shea, J.J. FEBS Lett. (1995)
- A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities. Vidal, G.A., Clark, D.E., Marrero, L., Jones, F.E. Oncogene (2007)
- Effects of thrombopoietin, interleukin-3 and the kinase inhibitor K-252a on growth and polyploidization of the megakaryocytic cell line M-07e. Quentmeier, H., Zaborski, M., Drexler, H.G. Leukemia (1998)
- Cytokine-like effects of prolactin in human mononuclear and polymorphonuclear leukocytes. Dogusan, Z., Hooghe, R., Verdood, P., Hooghe-Peters, E.L. J. Neuroimmunol. (2001)
- Diabetic LDL inhibits cell-cycle progression via STAT5B and p21(waf). Brizzi, M.F., Dentelli, P., Pavan, M., Rosso, A., Gambino, R., Grazia De Cesaris, M., Garbarino, G., Camussi, G., Pagano, G., Pegoraro, L. J. Clin. Invest. (2002)
- Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Johnston, J.A., Bacon, C.M., Finbloom, D.S., Rees, R.C., Kaplan, D., Shibuya, K., Ortaldo, J.R., Gupta, S., Chen, Y.Q., Giri, J.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. Ehret, G.B., Reichenbach, P., Schindler, U., Horvath, C.M., Fritz, S., Nabholz, M., Bucher, P. J. Biol. Chem. (2001)
- Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. Martens, N., Uzan, G., Wery, M., Hooghe, R., Hooghe-Peters, E.L., Gertler, A. J. Biol. Chem. (2005)
- A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B. Verdier, F., Rabionet, R., Gouilleux, F., Beisenherz-Huss, C., Varlet, P., Muller, O., Mayeux, P., Lacombe, C., Gisselbrecht, S., Chretien, S. Mol. Cell. Biol. (1998)
- TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs. Sudarshan, C., Galon, J., Zhou, Y., O'Shea, J.J. J. Immunol. (1999)
- Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A. Kazansky, A.V., Kabotyanski, E.B., Wyszomierski, S.L., Mancini, M.A., Rosen, J.M. J. Biol. Chem. (1999)