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Gene Review

bvgA  -  virulence factors transcription regulator...

Bordetella pertussis Tohama I

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Disease relevance of bvgA


High impact information on bvgA


Biological context of bvgA

  • The vector was used in a scheme called allelic retrieval that exploits two cross-overs between cloned plasmid and native chromosomal sequences flanking the bvgA gene [7].
  • The regulatory regions found upstream of fhaB and bvgA which are involved in protein binding both contain the sequence TTTCCTA [8].
  • In this study a series of lacZYA fusions containing deletions in either the fhaB or bvgA promoter regions was used to identify cis-acting regulatory regions required for bvg activation of these two genes [8].
  • We conclude from these data that bvgA, bvgB, and bvgC comprise an operon encoding the components essential for coordinate regulation and sensory transduction [3].
  • Our data show that overexpression of the bvgA gene from a strong heterologous promoter results in transcriptional activation of the fhaB::lacZYA fusion even in the absence of the bvgB and bvgC products [3].

Other interactions of bvgA


  1. Autogenous regulation of the Bordetella pertussis bvgABC operon. Roy, C.R., Miller, J.F., Falkow, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Isolation and characterization of Bordetella avium phase variants. Gentry-Weeks, C.R., Provence, D.L., Keith, J.M., Curtiss, R. Infect. Immun. (1991) [Pubmed]
  3. The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes. Roy, C.R., Miller, J.F., Falkow, S. J. Bacteriol. (1989) [Pubmed]
  4. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Aricó, B., Miller, J.F., Roy, C., Stibitz, S., Monack, D., Falkow, S., Gross, R., Rappuoli, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis. Jones, A.M., Boucher, P.E., Williams, C.L., Stibitz, S., Cotter, P.A. Mol. Microbiol. (2005) [Pubmed]
  6. Structural and genetic analysis of the bvg locus in Bordetella species. Aricò, B., Scarlato, V., Monack, D.M., Falkow, S., Rappuoli, R. Mol. Microbiol. (1991) [Pubmed]
  7. Allelic retrieval: a scheme to facilitate the repeated isolation of a specific segment of the Bordetella pertussis chromosome. Stibitz, S. Gene (1998) [Pubmed]
  8. Identification of Bordetella pertussis regulatory sequences required for transcriptional activation of the fhaB gene and autoregulation of the bvgAS operon. Roy, C.R., Falkow, S. J. Bacteriol. (1991) [Pubmed]
  9. Newly identified genes involved in the signal transduction of Escherichia coli K-12. Utsumi, R., Katayama, S., Taniguchi, M., Horie, T., Ikeda, M., Igaki, S., Nakagawa, H., Miwa, A., Tanabe, H., Noda, M. Gene (1994) [Pubmed]
  10. Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants. Stibitz, S. J. Bacteriol. (1994) [Pubmed]
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