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Gene Review

SNORA69  -  small nucleolar RNA, H/ACA box 69

Homo sapiens

Synonyms: RNU69, U69, U69A
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Disease relevance of SNORA69

  • For the autophosphorylation reaction, the Michaelis constants for ATP of baculovirus-expressed HHV-6A and HHV-6B U69 were calculated to be 44 and 11 microM, respectively [1].
  • We analyzed whether the U69 ORF alone was capable of conferring GCV sensitivity on baculoviruses BV6AU69 and BV6BU69 [1].

High impact information on SNORA69

  • It has been reported that insertion of U69 into baculovirus confers sensitivity to ganciclovir in insect cells (J Virol 73:3284-3291, 1999) [2].
  • The protein encoded by the U69 open reading frame (ORF) of human herpesvirus 6 (HHV-6) has been predicted to be a protein kinase [1].
  • Nickel agarose and antibody affinity chromatography was used to purify the proteins to homogeneity and when incubated with [gamma-32P]ATP, both U69 proteins became phosphorylated on predominantly serine residues [1].
  • In addition, a "microhelix" was synthesized, which consists of seven base pairs of the acceptor stem of yeast tRNA(Phe) connected by a six-nucleotide loop and contains a mismatch involving residues G4 and U69 [3].
  • The effects of i.v. dynorphin A(1-17) and its main nonopioid biotransformation fragment, dynorphin A(2-17), were compared in rhesus monkeys with those of the selective kappa-opioid agonist, U69, 593, in assays of operant behavior, thermal antinociception, and neuroendocrine function (prolactin release) [4].

Associations of SNORA69 with chemical compounds

  • However, MERF had little influence on the specific binding of [3H]DPDPE, [3H]U69 and [3H]diprenorphine ([3H]DIP) in the presence of 1 microM each of DAMGO, DPDPE and U69 [5].
  • Specific binding of [3H]MERF was inhibited by DAMGO, Tyr-D-Arg-Phe-Sar(TAPS), bremazocine and ethylketocyclazocine (EKC), but not by U69,593 (U69) and DPDPE [5].


  1. The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses. Ansari, A., Emery, V.C. J. Virol. (1999) [Pubmed]
  2. Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir. De Bolle, L., Michel, D., Mertens, T., Manichanh, C., Agut, H., De Clercq, E., Naesens, L. Mol. Pharmacol. (2002) [Pubmed]
  3. Recognition of G-U mismatches by tris(4,7-diphenyl-1,10-phenanthroline)rhodium(III). Chow, C.S., Barton, J.K. Biochemistry (1992) [Pubmed]
  4. Effects of systemically administered dynorphin A(1-17) in rhesus monkeys. Butelman, E.R., Harris, T.J., Perez, A., Kreek, M.J. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  5. Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat. Kim, K.W., Woo, R.S., Kim, C.J., Cheong, Y.P., Kim, J.K., Kwun, J., Cho, K.P. Life Sci. (2000) [Pubmed]
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