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STEAP1  -  six transmembrane epithelial antigen of...

Homo sapiens

Synonyms: Metalloreductase STEAP1, PRSS24, STEAP, Six-transmembrane epithelial antigen of prostate 1
 
 
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Disease relevance of STEAP1

  • Protein analysis located STEAP at the cell surface of prostate-cancer cell lines [1].
  • This gene, named STEAP for six-transmembrane epithelial antigen of the prostate, is expressed predominantly in human prostate tissue and is up-regulated in multiple cancer cell lines, including prostate, bladder, colon, ovarian, and Ewing sarcoma [1].
  • More importantly, these CTLs were able to respond to tumor cells that express HLA-A2 and STEAP (colon, bladder, prostate, Ewing's sarcoma, and melanoma) [2].
  • Six-transmembrane epithelial antigen of the prostate (STEAP) is expressed predominantly in human prostate tissue and in other common malignancies including prostate, bladder, colon, and ovarian carcinomas, and in Ewing's sarcoma, suggesting that it could function as an almost universal tumor antigen [2].
 

High impact information on STEAP1

References

  1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. Hubert, R.S., Vivanco, I., Chen, E., Rastegar, S., Leong, K., Mitchell, S.C., Madraswala, R., Zhou, Y., Kuo, J., Raitano, A.B., Jakobovits, A., Saffran, D.C., Afar, D.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes. Rodeberg, D.A., Nuss, R.A., Elsawa, S.F., Celis, E. Clin. Cancer Res. (2005) [Pubmed]
  3. ACRATA: a novel electron transfer domain associated to apoptosis and cancer. Sanchez-Pulido, L., Rojas, A.M., Valencia, A., Martinez-A, C., Andrade, M.A. BMC Cancer (2004) [Pubmed]
 
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