Disease relevance of STEAP2

• As a cell-surface antigen, STEAP2 is a potential diagnostic or therapeutic target in prostate cancer [1].
• Long-term Food Stamp Program participation is positively related to simultaneous overweight in young daughters and obesity in mothers [2].
• The Breast Cancer Research Stamp: sticking with a great idea [3].

Psychiatry related information on STEAP2

• Data from tests administered by substance abuse testing providers were combined with information from Medicaid, Food Stamp, cash assistance and Unemployment Insurance files to examine differences between the two groups [4].

High impact information on STEAP2

• Consistent with this notion, in situ analysis of human prostate cancer specimens indicated that STAMP1 is expressed exclusively in the epithelial cells of the prostate and its expression is significantly increased in prostate tumors compared with normal glands [5].
• STAMP1 is highly expressed in the androgen-sensitive, androgen receptor-positive prostate cancer cell line LNCaP, but not in androgen receptor-negative prostate cancer cell lines PC-3 and DU145 [5].
• STAMP1 also localizes to vesicular tubular structures in the cytosol and colocalizes with the early endosome antigen 1 (EEA1), suggesting that it may be involved in the secretory/endocytic pathways [5].
• Using a form of STAMP1 labeled with green fluorescent protein in quantitative time-lapse and immunofluorescence confocal microscopy, we show that STAMP1 is localized to the Golgi complex, predominantly to the trans-Golgi network, and to the plasma membrane [5].
• We have identified a novel gene, six transmembrane protein of prostate 2 (STAMP2), named for its high sequence similarity to the recently identified STAMP1 gene [6].

Chemical compound and disease context of STEAP2

• Of the prostate cancer cell lines, STEAP2 was expressed in significant levels only in androgen-responsive LNCaP [1].

Biological context of STEAP2

• BACKGROUND: Recently, several members of a vertebrate protein family containing a six trans-membrane (6TM) domain and involved in apoptosis and cancer (e.g. STEAP, STAMP1, TSAP6), have been identified in Golgi and cytoplasmic membranes [7].
• Prostate cancer associated with CYP17 genotype [8].
• We examined the effects of household participation in the Food Stamp and WIC Nutrition Programs on the nutrient intakes of preschoolers using data from the 1989-1991 Continuing Survey of Food Intake by Individuals [9].
• Ethnicity and Food Stamp program participation: effect upon dietary intakes of low-income mothers served by a north Florida family practice center [10].
• This implies that the proposed SVDU-IPCA method gives a close approximation to the batch-mode PCA method [11].

Anatomical context of STEAP2

• Green fluorescent protein fusion construct indicated that the STEAP2 protein is localized mainly in the plasma membrane [1].
• Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein [12].
• Twenty-four newly diagnosed (median age 42) responding metastatic breast cancer patients underwent HDCT (Stamp V) and stem cell support as their initial treatment [13].

Associations of STEAP2 with chemical compounds

• Twenty-three patients received sequential high-dose therapies with the first consisting of high-dose melphalan and the second of Stamp V [14].
• The high-dose chemotherapy consisted of the Stamp V regimen in all patients comprising cyclophosphamide, thiotepa and carboplatin (CTCb) [14].
• Among participants in the Food Stamp program, mean intakes of protein, niacin, and soft drinks were significantly higher for blacks than for whites [10].
• Hence, we performed a modified 25-hydroxyvitamin D (25-OHD) absorption test Stamp in 15 healthy controls, 31 patients with CD and 10 patients with PI [15].
• Selective Beta Blocker Tenolol (IPCA) 50 mg [16].

Other interactions of STEAP2

• Food stamp use is defined as an individual being in a household that has used the Food Stamp Program at some point during the year [17].

Analytical, diagnostic and therapeutic context of STEAP2

• Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer [5].
• Furthermore, STAMP1 expression is significantly lower in the androgen-dependent human prostate xenograft CWR22 compared with the relapsed derivative CWR22R, suggesting that its expression may be deregulated during prostate cancer progression [5].
• However, coxiella-like organisms were demonstrated in valvular material with Köster, Stamp, and Giemsa stains, and the organisms were grown in cell culture [18].
• Guar gum (GG) was crosslinked with increasing amounts of trisodium trimetaphosophate (STMP) to reduce its swelling properties for use as a vehicle in oral delivery formulations, especially drug delivery systems aimed at localizing drugs in the distal portions of the small bowel [19].
• Therefore, the Food Stamp Program was not consistently associated with better iron nutrition of the elderly poor in NHANES I and II [20].

References