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Gene Review

Acvr1c  -  activin A receptor, type IC

Mus musculus

Synonyms: ACTR-IC, ACVRLK7, ALK-7, ALK7, Activin receptor type IC, ...
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High impact information on Acvr1c

  • Two type I serine/threonine kinase receptors have been identified for Nodal, ALK4 and ALK7 [1].
  • None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB coreceptors, including heart malformations, pulmonary isomerism, right-sided gut, and spleen hypoplasia, were observed in mice lacking ALK7 [1].
  • ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse [1].
  • ALK7 and ALK4 were highly expressed in interdigital regions of the developing limb bud [1].
  • Finally, the histological organization of the cerebellum, cortex, and hippocampus, all sites of significant ALK7 expression in the rodent brain, appeared normal in ALK7 mutant mice [1].

Anatomical context of Acvr1c


  1. ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Jörnvall, H., Reissmann, E., Andersson, O., Mehrkash, M., Ibáñez, C.F. Mol. Cell. Biol. (2004) [Pubmed]
  2. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Tsuchida, K., Nakatani, M., Yamakawa, N., Hashimoto, O., Hasegawa, Y., Sugino, H. Mol. Cell. Endocrinol. (2004) [Pubmed]
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