High impact information on Acvr1c

• Two type I serine/threonine kinase receptors have been identified for Nodal, ALK4 and ALK7 [1].
• None of the left-right patterning abnormalities and organogenesis defects identified in mice carrying mutations in Nodal or in genes encoding ActRIIA and ActRIIB coreceptors, including heart malformations, pulmonary isomerism, right-sided gut, and spleen hypoplasia, were observed in mice lacking ALK7 [1].
• ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse [1].
• ALK7 and ALK4 were highly expressed in interdigital regions of the developing limb bud [1].
• Finally, the histological organization of the cerebellum, cortex, and hippocampus, all sites of significant ALK7 expression in the rodent brain, appeared normal in ALK7 mutant mice [1].

Anatomical context of Acvr1c

• ALK7 is an orphan receptor serine/threonine kinase expressed in neuroendocrine tissues including pancreatic islets [2].

References