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Gene Review

ACVR1C  -  activin A receptor, type IC

Homo sapiens

Synonyms: ACTR-IC, ACVRLK7, ALK-7, ALK7, Activin receptor type IC, ...
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Disease relevance of ACVR1C

  • Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7 [1].
  • We also confirmed this finding in Hep3B human hepatoma cells by transiently transfecting the constitutively active form of ALK7, ALK7(T194D) [2].
  • Cells infected with active ALK7 adenovirus showed an apoptotic-positive phenotype, as opposed to those that were infected with a control protein [2].
  • Infection with Ad-caALK7 of MIN6 insulinoma cells, in which ALK7 has previously been shown to be endogenously expressed, led to a marked increase in the phosphorylation of Smad2, a signaling molecule also used by TGF-betas and activins [3].

High impact information on ACVR1C


Biological context of ACVR1C


Anatomical context of ACVR1C


Associations of ACVR1C with chemical compounds

  • The full-length ALK7 has 493 amino acids and exhibits all characteristics of TGFbeta type I receptors, including an activin receptor-binding domain, a transmembrane domain, a GS domain, and a serine/threonine kinase domain [6].

Regulatory relationships of ACVR1C

  • Thus, ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap [7].

Other interactions of ACVR1C


Analytical, diagnostic and therapeutic context of ACVR1C


  1. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. Xu, G., Zhong, Y., Munir, S., Yang, B.B., Tsang, B.K., Peng, C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  2. Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells. Kim, B.C., van Gelder, H., Kim, T.A., Lee, H.J., Baik, K.G., Chun, H.H., Lee, D.A., Choi, K.S., Kim, S.J. J. Biol. Chem. (2004) [Pubmed]
  3. cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). Bondestam, J., Huotari, M.A., Morén, A., Ustinov, J., Kaivo-Oja, N., Kallio, J., Horelli-Kuitunen, N., Aaltonen, J., Fujii, M., Moustakas, A., Ten Dijke, P., Otonkoski, T., Ritvos, O. Cytogenet. Cell Genet. (2001) [Pubmed]
  4. The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Reissmann, E., Jörnvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M.G., Ibáñez, C.F., Brivanlou, A.H. Genes Dev. (2001) [Pubmed]
  5. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. Munir, S., Xu, G., Wu, Y., Yang, B., Lala, P.K., Peng, C. J. Biol. Chem. (2004) [Pubmed]
  6. Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. Roberts, H.J., Hu, S., Qiu, Q., Leung, P.C., Caniggia, I., Gruslin, A., Tsang, B., Peng, C. Biol. Reprod. (2003) [Pubmed]
  7. Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Xu, G., Zhou, H., Wang, Q., Auersperg, N., Peng, C. Mol. Cancer Res. (2006) [Pubmed]
  8. Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Bernard, D.J., Lee, K.B., Santos, M.M. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  9. Tree-pollen allergy is efficiently treated by short-term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens. Balda, B.R., Wolf, H., Baumgarten, C., Klimek, L., Rasp, G., Kunkel, G., Müller, S., Mann, W., Hauswald, B., Heppt, W., Przybilla, B., Amon, U., Bischoff, R., Becher, G., Hummel, S., Frosch, P.J., Rustemeyer, T., Jäger, L., Brehler, R., Luger, T., Schnitker, J. Allergy (1998) [Pubmed]
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