Gene Review:
ACVR1C - activin A receptor, type IC
Homo sapiens
Synonyms:
ACTR-IC, ACVRLK7, ALK-7, ALK7, Activin receptor type IC, ...
- Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. Xu, G., Zhong, Y., Munir, S., Yang, B.B., Tsang, B.K., Peng, C. J. Clin. Endocrinol. Metab. (2004)
- Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells. Kim, B.C., van Gelder, H., Kim, T.A., Lee, H.J., Baik, K.G., Chun, H.H., Lee, D.A., Choi, K.S., Kim, S.J. J. Biol. Chem. (2004)
- cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). Bondestam, J., Huotari, M.A., Morén, A., Ustinov, J., Kaivo-Oja, N., Kallio, J., Horelli-Kuitunen, N., Aaltonen, J., Fujii, M., Moustakas, A., Ten Dijke, P., Otonkoski, T., Ritvos, O. Cytogenet. Cell Genet. (2001)
- The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Reissmann, E., Jörnvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M.G., Ibáñez, C.F., Brivanlou, A.H. Genes Dev. (2001)
- Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. Munir, S., Xu, G., Wu, Y., Yang, B., Lala, P.K., Peng, C. J. Biol. Chem. (2004)
- Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. Roberts, H.J., Hu, S., Qiu, Q., Leung, P.C., Caniggia, I., Gruslin, A., Tsang, B., Peng, C. Biol. Reprod. (2003)
- Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Xu, G., Zhou, H., Wang, Q., Auersperg, N., Peng, C. Mol. Cancer Res. (2006)
- Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Bernard, D.J., Lee, K.B., Santos, M.M. Reprod. Biol. Endocrinol. (2006)
- Tree-pollen allergy is efficiently treated by short-term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens. Balda, B.R., Wolf, H., Baumgarten, C., Klimek, L., Rasp, G., Kunkel, G., Müller, S., Mann, W., Hauswald, B., Heppt, W., Przybilla, B., Amon, U., Bischoff, R., Becher, G., Hummel, S., Frosch, P.J., Rustemeyer, T., Jäger, L., Brehler, R., Luger, T., Schnitker, J. Allergy (1998)