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Gene Review

NSG1  -  neuron specific gene family member 1

Homo sapiens

Synonyms: D4S234, D4S234E, NEEP21, P21
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High impact information on D4S234E

  • These results indicate that NEEP21-GRIP1 binding is crucial for GluR2-AMPAR sorting through endosomes and their recruitment to the plasma membrane, providing a first molecular mechanism to differentially regulate AMPAR subunit cycling in internal compartments [1].
  • Syntaxins 12/13 regulates glutamate receptor recycling via its interaction with neuron-enriched endosomal protein of 21 kDa (NEEP21) [2].
  • Migration of granule cells from the external granular layer was retarded, as was the polarization and branching of Purkinje cells, resulting in a less complex branching pattern and a smaller dendritic tree at P21 [3].
  • CA1 hippocampal area slices from P21 rats were frozen at -173 degrees C under high pressure to reduce crystal formation, and synapses on dendritic spines were analysed after cryosubstitution and embedding [4].
  • Immunofluorescence microscopy, using an antipeptide antibody, established that the human D4S234 protein preferentially localized to the nucleus of mitotic cultured cells [5].

Analytical, diagnostic and therapeutic context of D4S234E

  • Pulldown assays and atomic force microscopy indicate that phosphorylated GRIP shows reduced binding to NEEP21 [6].
  • Sequence analyses of the human and mouse D4S234 proteins identified an evolutionarily conserved hydrophobic sequence and a consensus nuclear localization signal in both genes [5].


  1. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. Steiner, P., Alberi, S., Kulangara, K., Yersin, A., Sarria, J.C., Regulier, E., Kasas, S., Dietler, G., Muller, D., Catsicas, S., Hirling, H. EMBO J. (2005) [Pubmed]
  2. SNAREs in neurons - beyond synaptic vesicle exocytosis (Review). Wang, Y., Tang, B.L. Mol. Membr. Biol. (2006) [Pubmed]
  3. Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver. Krysko, O., Hulshagen, L., Janssen, A., Sch??tz, G., Klein, R., De Bruycker, M., Espeel, M., Gressens, P., Baes, M. J. Neurosci. Res. (2007) [Pubmed]
  4. Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography. Rostaing, P., Real, E., Siksou, L., Lechaire, J.P., Boudier, T., Boeckers, T.M., Gertler, F., Gundelfinger, E.D., Triller, A., Marty, S. Eur. J. Neurosci. (2006) [Pubmed]
  5. Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons. Carlock, L., Vo, T., Lorincz, M., Walker, P.D., Bessert, D., Wisniewski, D., Dunbar, J.C. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  6. Phosphorylation of glutamate receptor interacting protein 1 regulates surface expression of glutamate receptors. Kulangara, K., Kropf, M., Glauser, L., Magnin, S., Alberi, S., Yersin, A., Hirling, H. J. Biol. Chem. (2007) [Pubmed]
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