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Gene Review

atpA  -  ATP synthase CF1 alpha chain

Chlamydomonas reinhardtii

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High impact information on atpA

  • Cloned chloroplast DNA sequences, into which had been inserted chimeric genes composed of the GUS coding sequence reporter under transcriptional control of chloroplast promoters for the C. reinhardtii atpA, atpB, and rbcL genes, were introduced into the cells on microprojectiles [1].
  • When expressed from a chimeric mRNA containing the atpA 5' untranslated region, cytochrome f no longer showed an assembly-dependent regulation of translation [2].
  • The mutation also affects the atpA gene cluster; polycistronic mRNAs with psbI or cemA 3'-ends accumulate to a lower level in the crp3 background [3].
  • We identified two neighboring missense mutations in the chloroplast atpA gene which are responsible for the defect of ATP synthase assembly in the FUD16 mutant from Chlamydomonas reinhardtii [4].
  • We expressed a chloroplast luciferase gene, luxCt, in C. reinhardtii chloroplasts under the control of the ATPase alpha subunit (atpA) or psbA promoter and 5' untranslated regions (UTRs) and the rubisco large subunit (rbcL) 3' UTR [5].

Biological context of atpA

  • Complete DNA sequence of the Chlamydomonas reinhardtii chloroplast atpA gene [6].
  • On the other hand, the psbD and atpA coding region portions did not affect chimeric gene expression [7].
  • At variance with the subset of these mutations that affect mRNA stability through the 5' UTR of a single chloroplast transcript, the mutated version of MDA1 acts on the coding region of the atpA message [8].
  • Among the 18 protein-coding genes examined, atpA and atpF of C. moewusii constitute the unique set of closely linked genes which is shared with land plant chloroplast genomes [9].

Other interactions of atpA

  • The atpA, atpB and psaB mRNAs were most abundant in the first 6 hours of the light period and decreased to about 15% of maximum in the dark [10].


  1. Transcriptional analysis of endogenous and foreign genes in chloroplast transformants of Chlamydomonas. Blowers, A.D., Ellmore, G.S., Klein, U., Bogorad, L. Plant Cell (1990) [Pubmed]
  2. Translation of cytochrome f is autoregulated through the 5' untranslated region of petA mRNA in Chlamydomonas chloroplasts. Choquet, Y., Stern, D.B., Wostrikoff, K., Kuras, R., Girard-Bascou, J., Wollman, F.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Target and specificity of a nuclear gene product that participates in mRNA 3'-end formation in Chlamydomonas chloroplasts. Levy, H., Kindle, K.L., Stern, D.B. J. Biol. Chem. (1999) [Pubmed]
  4. Chloroplasts can accommodate inclusion bodies. Evidence from a mutant of Chlamydomonas reinhardtii defective in the assembly of the chloroplast ATP synthase. Ketchner, S.L., Drapier, D., Olive, J., Gaudriault, S., Girard-Bascou, J., Wollman, F.A. J. Biol. Chem. (1995) [Pubmed]
  5. Development of a luciferase reporter gene, luxCt, for Chlamydomonas reinhardtii chloroplast. Mayfield, S.P., Schultz, J. Plant J. (2004) [Pubmed]
  6. Complete DNA sequence of the Chlamydomonas reinhardtii chloroplast atpA gene. Leu, S., Schlesinger, J., Michaels, A., Shavit, N. Plant Mol. Biol. (1992) [Pubmed]
  7. Effect of coding regions on chloroplast gene expression in Chlamydomonas reinhardtii. Kasai, S., Yoshimura, S., Ishikura, K., Takaoka, Y., Kobayashi, K., Kato, K., Shinmyo, A. J. Biosci. Bioeng. (2003) [Pubmed]
  8. A dominant nuclear mutation in Chlamydomonas identifies a factor controlling chloroplast mRNA stability by acting on the coding region of the atpA transcript. Drapier, D., Girard-Bascou, J., Stern, D.B., Wollman, F.A. Plant J. (2002) [Pubmed]
  9. The chloroplast genome of the green alga Chlamydomonas moewusii: localization of protein-coding genes and transcriptionally active regions. Turmel, M., Lemieux, B., Lemieux, C. Mol. Gen. Genet. (1988) [Pubmed]
  10. Cell cycle-dependent transcriptional and post-transcriptional regulation of chloroplast gene expression in Chlamydomonas reinhardtii. Leu, S., White, D., Michaels, A. Biochim. Biophys. Acta (1990) [Pubmed]
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