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Gene Review:

ADAMDEC1 - ADAM-like, decysin 1

Homo sapiens

Synonyms: A disintegrin and metalloproteinase domain-like protein decysin-1, ADAM DEC1, ADAM-like protein decysin-1, M12.219

Bates, E.E. et al., Papaspyridonos, M. et al.

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High impact information on ADAMDEC1

The relatedness of ADAMDEC1, ADAM7, and ADAM28 suggests that these proteases share a similar function [1].
Our results suggest that ADAMDEC1 has arisen by partial gene duplication from an ancestral gene at this locus and has acquired a novel function [1].
ADAMDEC1 is expressed in the immune system, by dendritic cells and macrophages [1].
The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12 [1].
Eighteen of these genes have not been associated previously with plaque instability, including the metalloproteinase, ADAMDEC1 (approximately 37-fold), retinoic acid receptor responder-1 (approximately 5-fold), and cysteine protease legumain (approximately 3-fold) [2].

References

The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. Bates, E.E., Fridman, W.H., Mueller, C.G. Immunogenetics (2002) [Pubmed]
Novel candidate genes in unstable areas of human atherosclerotic plaques. Papaspyridonos, M., Smith, A., Burnand, K.G., Taylor, P., Padayachee, S., Suckling, K.E., James, C.H., Greaves, D.R., Patel, L. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ADAMDEC1	Canis lupus familiaris
ADAMDEC1	Macaca mulatta
Adamdec1	Mus musculus
ADAMDEC1	Pan troglodytes

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