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Gene Review

ADAM7  -  ADAM metallopeptidase domain 7

Homo sapiens

Synonyms: ADAM 7, ADAM-7, Disintegrin and metalloproteinase domain-containing protein 7, EAPI, GP-83, ...
 
 
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Disease relevance of ADAM7

  • We recently identified the genes encoding the guinea pig cytomegalovirus (GPCMV) homologs of the upper and lower matrix proteins of human CMV, pp71 (UL82) and pp65 (UL83), which we designated GP82 and GP83, respectively [1].
 

High impact information on ADAM7

  • Comparison of the one-step growth kinetics of the GP83 mutant (vAM409) and wild-type GPCMV indicated that GP83 protein is not required for viral replication in tissue culture [1].
  • Conventional homologous recombination was used to generate a GP83 mutant to examine the role of GP83 in the viral life cycle [1].
  • The vAM409 mutant was significantly attenuated for dissemination in immunocompromised strain 2 guinea pigs, suggesting that the GP83 protein is essential for full pathogenicity in vivo [1].
  • According to the DNA sequences elucidated in the Human Genome Project, h-ADAM7 was located at chromosome 8p22 [2].
  • In this study, a 2.1-kilobase (kb) GP-83-expressing insert was isolated from a cDNA library of human epididymis by immunoscreening using GP-83-specific antiserum [2].
 

Biological context of ADAM7

  • The 5' end rapid amplification of cDNA ends (RACE) and 3'-RACE of the 2.1-kb insert elucidated two isoforms of GP-83-encoding cDNA sequences, an alpha-form of 3451 base pairs (bp) and beta-form of 2643 bp [2].
  • WGA-binding granules and positive binding sites of GP-83 were also detected in the cytoplasm [3].
  • The results indicate that WGA-binding proteins may be synthesized by the corpus epididymal epithelial cells of human and GP-83 may play an important role in sperm maturation [3].
 

Anatomical context of ADAM7

 

Associations of ADAM7 with chemical compounds

  • The present study characterizes the integrin binding properties of the disintegrin-like domains of human ADAM7, ADAM28 and ADAM33 with the integrins alpha4beta1, alpha4beta7 and alpha9beta1 [4].
 

Other interactions of ADAM7

  • These results establish that ADAM7 and ADAM28 are recognized by the leucocyte integrins alpha4beta1, alpha4beta7 and alpha9beta1 [4].
  • On Western blots probed with WGA and Con-A, glycoproteins of 83 kDa (GP-83) and 39 kDa (GP-39) were identified in the sperm extracts, epididymal fluid and tissue extracts of the corpus and cauda epididymides, but not in the caput [6].
 

Analytical, diagnostic and therapeutic context of ADAM7

  • In this study, GP-83 was purified from human seminal fluid by DEAE-ion exchange, gel filtration chromatography and preparative gel elution [5].

References

 
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