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Gene Review

mpl  -  zinc metallopeptidase

Listeria monocytogenes serotype 4b str. F2365

 
 
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Disease relevance of mpl

  • In vitro transcription of the Listeria monocytogenes virulence genes inlC and mpl reveals overlapping PrfA-dependent and -independent promoters that are differentially activated by GTP [1].
 

High impact information on mpl

  • Direct frequency analyses of immune splenocytes, however, revealed that LLO 91-99 and p60 217-225 elicit dominant T cell responses, while p60 449-457 and mpl 84-92 elicit minor, subdominant responses [2].
  • The life-time of the prfA, plcA, and mpl transcripts is short [3].
  • The entire mpl gene was cloned in a plasmid able to replicate in L. monocytogenes [4].
  • The maturation of the 33-kDa proenzyme to the 29-kDa phosphatidylcholine phospholipase C (PC-PLC) of Listeria monocytogenes requires the production of the zinc metalloprotease encoded by mpl, the proximal gene of the lecithinase operon [4].
  • The most discriminatory 600-bp fragments identified in the housekeeping and stress response genes differentiated the isolates into 8 to 10 subtypes; intergenic region sequences yielded 8 and 12 allelic types based on 335- and 242-bp sequences for hly-mpl and plcA-hly, respectively [5].
 

Other interactions of mpl

  • Synthesis of p60 in L. monocytogenes was significantly lower when the iap gene was placed under the control of the actA or the mpl promoter [6].
 

Analytical, diagnostic and therapeutic context of mpl

  • It was suggested that PCR detection of genes prfA, mpl, or plcB may not be sufficient to detect virulent strains of L. monocytogenes [7].

References

  1. In vitro transcription of the Listeria monocytogenes virulence genes inlC and mpl reveals overlapping PrfA-dependent and -independent promoters that are differentially activated by GTP. Luo, Q., Rauch, M., Marr, A.K., Müller-Altrock, S., Goebel, W. Mol. Microbiol. (2004) [Pubmed]
  2. MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL. Busch, D.H., Pamer, E.G. J. Immunol. (1998) [Pubmed]
  3. Transcriptional regulation of prfA and PrfA-regulated virulence genes in Listeria monocytogenes. Bohne, J., Sokolovic, Z., Goebel, W. Mol. Microbiol. (1994) [Pubmed]
  4. The zinc metalloprotease of Listeria monocytogenes is required for maturation of phosphatidylcholine phospholipase C: direct evidence obtained by gene complementation. Poyart, C., Abachin, E., Razafimanantsoa, I., Berche, P. Infect. Immun. (1993) [Pubmed]
  5. Rational design of DNA sequence-based strategies for subtyping Listeria monocytogenes. Cai, S., Kabuki, D.Y., Kuaye, A.Y., Cargioli, T.G., Chung, M.S., Nielsen, R., Wiedmann, M. J. Clin. Microbiol. (2002) [Pubmed]
  6. The Listeria monocytogenes iap gene as an indicator gene for the study of PrfA-dependent regulation. Bubert, A., Kestler, H., Götz, M., Böckmann, R., Goebel, W. Mol. Gen. Genet. (1997) [Pubmed]
  7. Correlation between the presence of virulence-associated genes as determined by PCR and actual virulence to mice in various strains of Listeria spp. Nishibori, T., Cooray, K., Xiong, H., Kawamura, I., Fujita, M., Mitsuyama, M. Microbiol. Immunol. (1995) [Pubmed]
 
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