Gene Review:
prfA - listeriolysin regulatory protein
Listeria monocytogenes serotype 4b str. F2365
- A prfA transposon mutant of Listeria monocytogenes F2365, a serotype 4b strain, is able to survive in the gastrointestinal tract but does not cause systemic infection of the spleens and livers of intragastrically inoculated mice. Faith, N., Uhlich, G., Luchansky, J.B., Neudeck, B., Czuprynski, C. Infect. Immun. (2005)
- Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis. Freitag, N.E., Youngman, P., Portnoy, D.A. J. Bacteriol. (1992)
- An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. Johansson, J., Mandin, P., Renzoni, A., Chiaruttini, C., Springer, M., Cossart, P. Cell (2002)
- New Listeria monocytogenes prfA* mutants, transcriptional properties of PrfA* proteins and structure-function of the virulence regulator PrfA. Vega, Y., Rauch, M., Banfield, M.J., Ermolaeva, S., Scortti, M., Goebel, W., Vázquez-Boland, J.A. Mol. Microbiol. (2004)
- Negative control of Listeria monocytogenes virulence genes by a diffusible autorepressor. Ermolaeva, S., Novella, S., Vega, Y., Ripio, M.T., Scortti, M., Vázquez-Boland, J.A. Mol. Microbiol. (2004)
- Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA. Milohanic, E., Glaser, P., Coppée, J.Y., Frangeul, L., Vega, Y., Vázquez-Boland, J.A., Kunst, F., Cossart, P., Buchrieser, C. Mol. Microbiol. (2003)
- Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocytogenes: activation of NF-kappa B and upregulation of adhesion molecules and chemokines. Kayal, S., Lilienbaum, A., Poyart, C., Memet, S., Israel, A., Berche, P. Mol. Microbiol. (1999)
- Contributions of Listeria monocytogenes sigmaB and PrfA to expression of virulence and stress response genes during extra- and intracellular growth. Kazmierczak, M.J., Wiedmann, M., Boor, K.J. Microbiology (Reading, Engl.) (2006)
- Five Listeria monocytogenes genes preferentially expressed in infected mammalian cells: plcA, purH, purD, pyrE and an arginine ABC transporter gene, arpJ. Klarsfeld, A.D., Goossens, P.L., Cossart, P. Mol. Microbiol. (1994)
- Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Guzmán, C.A., Domann, E., Rohde, M., Bruder, D., Darji, A., Weiss, S., Wehland, J., Chakraborty, T., Timmis, K.N. Mol. Microbiol. (1996)
- Detection of a prfA-independent promoter responsible for listeriolysin gene expression in mutant Listeria monocytogenes strains lacking the PrfA regulator. Domann, E., Wehland, J., Niebuhr, K., Haffner, C., Leimeister-Wächter, M., Chakraborty, T. Infect. Immun. (1993)
- Internalin-mediated invasion of epithelial cells by Listeria monocytogenes is regulated by the bacterial growth state, temperature and the pleiotropic activator prfA. Dramsi, S., Kocks, C., Forestier, C., Cossart, P. Mol. Microbiol. (1993)
- A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity. Velge, P., Herler, M., Johansson, J., Roche, S.M., Témoin, S., Fedorov, A.A., Gracieux, P., Almo, S.C., Goebel, W., Cossart, P. Microbiology (Reading, Engl.) (2007)
- Regulation of hly expression in Listeria monocytogenes by carbon sources and pH occurs through separate mechanisms mediated by PrfA. Behari, J., Youngman, P. Infect. Immun. (1998)
- Positive selection of mutations leading to loss or reduction of transcriptional activity of PrfA, the central regulator of Listeria monocytogenes virulence. Herler, M., Bubert, A., Goetz, M., Vega, Y., Vazquez-Boland, J.A., Goebel, W. J. Bacteriol. (2001)
- How seryl-phosphorylated HPr inhibits PrfA, a transcription activator of Listeria monocytogenes virulence genes. Herro, R., Poncet, S., Cossart, P., Buchrieser, C., Gouin, E., Glaser, P., Deutscher, J. J. Mol. Microbiol. Biotechnol. (2005)
- A role for ActA in epithelial cell invasion by Listeria monocytogenes. Suárez, M., González-Zorn, B., Vega, Y., Chico-Calero, I., Vázquez-Boland, J.A. Cell. Microbiol. (2001)
- Detection of multiple virulence-associated genes of Listeria monocytogenes by PCR in artificially contaminated milk samples. Cooray, K.J., Nishibori, T., Xiong, H., Matsuyama, T., Fujita, M., Mitsuyama, M. Appl. Environ. Microbiol. (1994)
- Transcriptional regulation of prfA and PrfA-regulated virulence genes in Listeria monocytogenes. Bohne, J., Sokolovic, Z., Goebel, W. Mol. Microbiol. (1994)
- Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo. Freitag, N.E., Portnoy, D.A. Mol. Microbiol. (1994)
- Sensitive detection of viable Listeria monocytogenes by reverse transcription-PCR. Klein, P.G., Juneja, V.K. Appl. Environ. Microbiol. (1997)