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Gene Review

BAX  -  BCL2-associated X protein

Bos taurus

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Disease relevance of BAX

  • An independent laboratory study of the BAX for Screening/E. coli O157:H7 kit was conducted at the National Food Laboratory, Inc., Dublin, CA, to complete AOAC Performance Tested Method certification [1].

High impact information on BAX

  • Treatment with 500 micrometer H(2)O(2) causes apoptosis in FRTL-5 cells as evidenced by standard assays of apoptosis (i.e. terminal deoxynucleotidyl transferase deoxyuridine triphosphate-biotin nick end labeling, BAX expression, and poly(ADP-ribose) polymerase cleavage [2].
  • BAX expression intensity increased with progression of gestation and remained elevated in postpartum [3].
  • HA added to SOF + BSA, increased level of expression of epidermal growth factor (EGF)-II and decreased the levels of expression of BAX, SOX, and Ecad (P < 0.05) [4].
  • Frequently, genes that may be stress induced such as SOX, MnSOD, BAX, IFtau, and G6PD were highly transcribed in in vitro produced embryos and in embryos with slow developmental speed [5].

Biological context of BAX

  • We believe that the apoptosis of binucleate cells may be regulated by the balance of the BCL2A1 and BAX [3].

Analytical, diagnostic and therapeutic context of BAX

  • Screening bovine carcass sponge samples for Escherichia coli O157 using a short enrichment coupled with immunomagnetic separation and a polymerase chain reaction-based (BAX) detection stept [6].
  • In one field trial, 196 animals were sampled, and all samples were tested by culture, invA PCR on individual samples, invA PCR on pools of 5 samples, and BAX PCR on individual samples [7].


  1. Sensitivity and specificity of the test kit BAX for screening/E. coli O157:H7 in ground beef: independent laboratory study. Hochberg, A.M., Gerhardt, P.N., Cao, T.K., Ocasio, W., Barbour, W.M., Mrozinski, P.M. Journal of AOAC International. (2000) [Pubmed]
  2. Role of peroxiredoxins in regulating intracellular hydrogen peroxide and hydrogen peroxide-induced apoptosis in thyroid cells. Kim, H., Lee, T.H., Park, E.S., Suh, J.M., Park, S.J., Chung, H.K., Kwon, O.Y., Kim, Y.K., Ro, H.K., Shong, M. J. Biol. Chem. (2000) [Pubmed]
  3. Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta. Ushizawa, K., Takahashi, T., Kaneyama, K., Hosoe, M., Hashizume, K. Biol. Reprod. (2006) [Pubmed]
  4. Effects of hyaluronan, BSA, and serum on bovine embryo in vitro development, ultrastructure, and gene expression patterns. Palasz, A.T., Rodriguez-Martinez, H., Beltran-Bre??a, P., Perez-Garnelo, S., Martinez, M.F., Gutierrez-Adan, A., De la Fuente, J. Mol. Reprod. Dev. (2006) [Pubmed]
  5. Effect of speed of development on mRNA expression pattern in early bovine embryos cultured in vivo or in vitro. Gutiérrez-Adán, A., Rizos, D., Fair, T., Moreira, P.N., Pintado, B., de la Fuente, J., Boland, M.P., Lonergan, P. Mol. Reprod. Dev. (2004) [Pubmed]
  6. Screening bovine carcass sponge samples for Escherichia coli O157 using a short enrichment coupled with immunomagnetic separation and a polymerase chain reaction-based (BAX) detection stept. Kang, D.H., Barkocy-Gallagher, G.A., Koohmaraie, M., Siragusa, G.R. J. Food Prot. (2001) [Pubmed]
  7. Use of pooled samples for the detection of Salmonella in feces by polymerase chain reaction. Singer, R.S., Cooke, C.L., Maddox, C.W., Isaacson, R.E., Wallace, R.L. J. Vet. Diagn. Invest. (2006) [Pubmed]
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