Gene Review:
BAX - BCL2-associated X protein
Homo sapiens
Synonyms:
Apoptosis regulator BAX, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
Emerich,
Jedryka,
Klimek,
Osiecka,
Urbański,
Ehrmann,
White,
Madry,
Kosmider,
Murray,
Kraszewska,
Baak,
Ochocki,
Söreide,
Kuwabara,
Janssen,
Marc Germain,
Jocelyn Milburn,
Vincent Duronio,
Jezdinská,
Urbanek,
Söiland,
Stelmachów,
Płuzańska,
Krc,
Bartkowiak,
Breborowicz,
Ziaja,
Zyner,
Wojcik,
Inanami,
Timorek,
Zieliński,
Kupryjańczyk,
Koláo,
Goluda,
Ułańska,
Liberski,
Debniak,
Pawlicki,
Rzepka-Górska,
Wilczok,
Ziółkowska,
Ehrmann,
Rembiszewska,
Karpińska,
Körner,
Takahashi,
Vojtések,
Lebda-Wyborny,
Galuszková,
Skop,
Wiaderkiewicz,
Chudecka-Głaz,
Szymańska,
Markowska,
- Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). Ravi, R., Bedi, A. Cancer Res. (2002)
- Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis. White, E. Cell Death Differ. (2006)
- Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma. Hermann, S., Sturm, I., Mrozek, A., Klosterhalfen, B., Hauptmann, S., Dörken, B., Daniel, P.T. Int. J. Cancer (2001)
- Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2. Schuyer, M., van der Burg, M.E., Henzen-Logmans, S.C., Fieret, J.H., Klijn, J.G., Look, M.P., Foekens, J.A., Stoter, G., Berns, E.M. Br. J. Cancer (2001)
- BCL-2 family: regulators of cell death. Chao, D.T., Korsmeyer, S.J. Annu. Rev. Immunol. (1998)
- Apoptosis in the failing human heart. Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J.A., Quaini, E., Di Loreto, C., Beltrami, C.A., Krajewski, S., Reed, J.C., Anversa, P. N. Engl. J. Med. (1997)
- Humanin peptide suppresses apoptosis by interfering with Bax activation. Guo, B., Zhai, D., Cabezas, E., Welsh, K., Nouraini, S., Satterthwait, A.C., Reed, J.C. Nature (2003)
- Role of BAX in the apoptotic response to anticancer agents. Zhang, L., Yu, J., Park, B.H., Kinzler, K.W., Vogelstein, B. Science (2000)
- G125A single-nucleotide polymorphism in the human BAX promoter affects gene expression. Moshynska, O., Moshynskyy, I., Misra, V., Saxena, A. Oncogene (2005)
- Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen. Kupryjańczyk, J., Szymańska, T., Madry, R., Timorek, A., Stelmachów, J., Karpińska, G., Rembiszewska, A., Ziółkowska, I., Kraszewska, E., Debniak, J., Emerich, J., Ułańska, M., Płuzańska, A., Jedryka, M., Goluda, M., Chudecka-Głaz, A., Rzepka-Górska, I., Klimek, M., Urbański, K., Breborowicz, J., Zieliński, J., Markowska, J. Br. J. Cancer (2003)
- Colocalization of BAX with BID and VDAC-1 in nimesulide-induced apoptosis of human colon adenocarcinoma COLO 205 cells. Godlewski, M.M., Gajkowska, B., Lamparska-Przybysz, M., Motyl, T. Anticancer Drugs (2002)
- Enhanced P53 and BAX gene expression and apoptosis in A549 cells by cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP. Kosmider, B., Wojcik, I., Osiecka, R., Bartkowiak, J., Zyner, E., Ochocki, J., Liberski, P. Investigational new drugs. (2005)
- Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Kim, H., Rafiuddin-Shah, M., Tu, H.C., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. Nat. Cell Biol. (2006)
- PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Yu, J., Wang, Z., Kinzler, K.W., Vogelstein, B., Zhang, L. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Regulation of apoptosis proteins in cancer cells by ubiquitin. Zhang, H.G., Wang, J., Yang, X., Hsu, H.C., Mountz, J.D. Oncogene (2004)
- Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8. Kovar, H., Jug, G., Printz, D., Bartl, S., Schmid, G., Wesierska-Gadek, J. Oncogene (2000)
- Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary. Kugu, K., Ratts, V.S., Piquette, G.N., Tilly, K.I., Tao, X.J., Martimbeau, S., Aberdeen, G.W., Krajewski, S., Reed, J.C., Pepe, G.J., Albrecht, E.D., Tilly, J.L. Cell Death Differ. (1998)
- The potential role of BAX and BCL-2 expression in diffuse alveolar damage. Guinee, D., Brambilla, E., Fleming, M., Hayashi, T., Rahn, M., Koss, M., Ferrans, V., Travis, W. Am. J. Pathol. (1997)
- Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines. Dey, S., Spring, P.M., Arnold, S., Valentino, J., Chendil, D., Regine, W.F., Mohiuddin, M., Ahmed, M.M. Clin. Cancer Res. (2003)
- Requirement of BAX for efficient adenovirus-induced apoptosis. Lomonosova, E., Subramanian, T., Chinnadurai, G. J. Virol. (2002)
- Germ line BAX alterations are infrequent in Li-Fraumeni syndrome. Barlow, J.W., Mous, M., Wiley, J.C., Varley, J.M., Lozano, G., Strong, L.C., Malkin, D. Cancer Epidemiol. Biomarkers Prev. (2004)
- Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator. Jungas, T., Motta, I., Duffieux, F., Fanen, P., Stoven, V., Ojcius, D.M. J. Biol. Chem. (2002)
- Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells. Inanami, O., Takahashi, K., Kuwabara, M. Int. J. Radiat. Biol. (1999)
- BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Strobel, T., Swanson, L., Korsmeyer, S., Cannistra, S.A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Xiang, J., Chao, D.T., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. Sala, A., Casella, I., Grasso, L., Bellon, T., Reed, J.C., Miyashita, T., Peschle, C. Cancer Res. (1996)
- Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene. Sturm, I., Papadopoulos, S., Hillebrand, T., Benter, T., Lück, H.J., Wolff, G., Dörken, B., Daniel, P.T. Int. J. Cancer (2000)
- BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Saito, M., Korsmeyer, S.J., Schlesinger, P.H. Nat. Cell Biol. (2000)
- LATS1 tumor suppressor regulates G2/M transition and apoptosis. Xia, H., Qi, H., Li, Y., Pei, J., Barton, J., Blackstad, M., Xu, T., Tao, W. Oncogene (2002)
- Embryo quality and production efficiency of porcine parthenotes is improved by phytohemagglutinin. Gupta, M.K., Uhm, S.J., Han, D.W., Lee, H.T. Mol. Reprod. Dev. (2007)
- MCL-1 inhibits BAX in the absence of MCL-1/BAX Interaction. Germain, M., Milburn, J., Duronio, V. J. Biol. Chem. (2008)
- An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Amundson, S.A., Myers, T.G., Scudiero, D., Kitada, S., Reed, J.C., Fornace, A.J. Cancer Res. (2000)
- Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. Zhang, H., Cowan-Jacob, S.W., Simonen, M., Greenhalf, W., Heim, J., Meyhack, B. J. Biol. Chem. (2000)
- Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif. Wong, L.Y., Matchett, G.A., Wilson, A.C. J. Virol. (2004)
- Microsatellite instability in colorectal cancer. Söreide, K., Janssen, E.A., Söiland, H., Körner, H., Baak, J.P. The British journal of surgery. (2006)
- Smooth muscle cell apoptosis in primary varicose veins. Urbanek, T., Skop, B., Wiaderkiewicz, R., Wilczok, T., Ziaja, K., Lebda-Wyborny, T., Pawlicki, K. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2004)
- Coexpression of genes involved in apoptosis in central nervous system neoplasms. Bruggers, C.S., Fults, D., Perkins, S.L., Coffin, C.M., Carroll, W.L. J. Pediatr. Hematol. Oncol. (1999)
- Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection. Ehrmann, J., Galuszková, D., Ehrmann, J., Krc, I., Jezdinská, V., Vojtések, B., Murray, P.G., Koláo, Z. Pathol. Oncol. Res. (2000)