Gene Review:
BCL2A1 - BCL2-related protein A1
Bos taurus
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High impact information on BCL2A1
- In the placentomes, in situ hybridization demonstrated that the BCL2A1 was limited in binucleate cells expressing various pregnancy-specific molecules like placental lactogen [1].
- All BCL2 homology domains (BH1, BH2, BH3, and BH4) in bovine BCL2A1 were conserved as well as in other mammalian BCL2A1 [1].
- The predicted amino acid sequence shared 78% homology with human BCL2A1 [1].
- We cloned a full-length bovine BCL2A1 cDNA with 725 nucleotides and an open-reading frame corresponding to a protein of 175 amino acids [1].
- Quantitative real-time RT-PCR detection exhibited a high-level expression of BCL2A1 in the conceptus at Day 21 of gestation, and it was expressed and increased in the extraembryonic membrane, cotyledon, and intercotyledon from implantation to term [1].
Biological context of BCL2A1
- We believe that the apoptosis of binucleate cells may be regulated by the balance of the BCL2A1 and BAX [1].
References
- Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta. Ushizawa, K., Takahashi, T., Kaneyama, K., Hosoe, M., Hashizume, K. Biol. Reprod. (2006) [Pubmed]
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