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Gene Review

G6PD  -  glucose-6-phosphate dehydrogenase

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Disease relevance of G6PD

  • Median corpuscular fragility showed a positive correlation with the severity of parasitemia (r=0.81, P<0.0005) and a negative correlation with the activities of GSH-Px (r=-0.78, P<0.0001), SOD (r=-0.71, P<0.0005), catalase (r=-0.53, P<0.018) and G6PD (r=-0.58, P<0.0005) [1].
  • Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides is a reliable internal standard for radiation-inactivation studies of membranes in the frozen state [2].
  • The glucose-6-phosphate dehydrogenase from Neisseria gonorrhoeae was inhibited by long-chain fatty acid acyl-coenzyme A derivatives [3].
  • 0. Kinetic and other characteristics of the enzyme are presented, and the possible role of glucose-6-phosphate dehydrogenase as a target for fatty acid toxicity in gonococci, mediated in the form of the acyl-coenzyme A derivatives, is discussed [3].
  • However, when activity per cell was adjusted for cell size, subcutaneous depots had greater fatty acid synthae, glucose 6-phosphate dehydrogenase, and NADP-malate dehydrogenase activities than omental and perirenal, indicating that other factors such as nutrient supply may restrict hypertrophy of carcass adipocytes [4].

High impact information on G6PD


Chemical compound and disease context of G6PD


Biological context of G6PD


Anatomical context of G6PD


Associations of G6PD with chemical compounds


Other interactions of G6PD

  • Levels of G6PD and HPRT RNA were also higher in female morulae and blastocysts than in males, but only G6PD levels were significantly different between the sexes [16].
  • Results showed that XIST expression was significantly higher (p < 0.05) in XXX cells compared to XX and XXY cells and that G6PD [17].
  • Activities of antioxidant enzymes, viz. glucose-6-phosphate dehydrogenase (G6PD) and glutamate peroxidase (GPx) were also significantly increased (p<0.01) in group II [10].
  • Frequently, genes that may be stress induced such as SOX, MnSOD, BAX, IFtau, and G6PD were highly transcribed in in vitro produced embryos and in embryos with slow developmental speed [18].
  • The assumed centromere transposition between HSAX and BTAX associated with the rearranged chromosome segments is supported by cytogenetic assignments of the genes BGN and G6PD to BTAX [19].

Analytical, diagnostic and therapeutic context of G6PD


  1. Evaluation of antioxidant status and oxidative stress in cattle naturally infected with Theileria annulata. Asri Rezaei, S., Dalir-Naghadeh, B. Vet. Parasitol. (2006) [Pubmed]
  2. Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides is a reliable internal standard for radiation-inactivation studies of membranes in the frozen state. McIntyre, J.O., Churchill, P. Anal. Biochem. (1985) [Pubmed]
  3. Glucose-6-phosphate dehydrogenase from Neisseria gonorrhoeae: partical characterization of the enzyme and inhibition by long-chain fatty acid acyl-coenzyme A derivatives. Cacciapuoti, A.F., Morse, S.A. Can. J. Microbiol. (1980) [Pubmed]
  4. Lipogenic enzyme activities in different adipose depots of Pirenaican and Holstein bulls and heifers taking into account adipocyte size. Eguinoa, P., Brocklehurst, S., Arana, A., Mendizabal, J.A., Vernon, R.G., Purroy, A. J. Anim. Sci. (2003) [Pubmed]
  5. Ribose intervention in the cardiac pentose phosphate pathway is not species-specific. Zimmer, H.G., Ibel, H., Suchner, U., Schad, H. Science (1984) [Pubmed]
  6. Carl Jung. Kyle, R.A., Shampo, M.A. JAMA (1978) [Pubmed]
  7. Phagocytosis of phenylhydrazine oxidized and G-6-PD-deficient red blood cells: the role of cell-bound immunoglobulins. Horn, S., Bashan, N., Gopas, J. Blood (1991) [Pubmed]
  8. In vitro production and nuclear transfer affect dosage compensation of the X-linked gene transcripts G6PD, PGK, and Xist in preimplantation bovine embryos. Wrenzycki, C., Lucas-Hahn, A., Herrmann, D., Lemme, E., Korsawe, K., Niemann, H. Biol. Reprod. (2002) [Pubmed]
  9. A comparative study on lipid peroxidation, activities of antioxidant enzymes and viability of cattle and buffalo bull spermatozoa during storage at refrigeration temperature. Nair, S.J., Brar, A.S., Ahuja, C.S., Sangha, S.P., Chaudhary, K.C. Anim. Reprod. Sci. (2006) [Pubmed]
  10. Status of Lipid Peroxidation, Some Antioxidant Enzymes and Erythrocytic Fragility of Crossbred Cattle Naturally Infected with Theileria annulata. Grewal, A., Ahuja, C.S., Singha, S.P., Chaudhary, K.C. Vet. Res. Commun. (2005) [Pubmed]
  11. High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells. Zhang, Z., Apse, K., Pang, J., Stanton, R.C. J. Biol. Chem. (2000) [Pubmed]
  12. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Leopold, J.A., Zhang, Y.Y., Scribner, A.W., Stanton, R.C., Loscalzo, J. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  13. Characterization of hybrids between bovine (MDBK) and mouse (L-cell) cell lines. Chinchar, V.G., Floyd, A.D., Chinchar, G.D., Taylor, M.W. Biochem. Genet. (1979) [Pubmed]
  14. Developmental competence of heifer oocytes selected using the brilliant cresyl blue (BCB) test. Pujol, M., López-Béjar, M., Paramio, M.T. Theriogenology (2004) [Pubmed]
  15. The bovine genes for phosphoglycerate kinase, glucose-6-phosphate dehydrogenase, alpha-galactosidase, and hypoxanthine phosphoribosyltransferase are linked to the X chromosome in cattle-mouse cell hybrids. Shimizu, N., Shimizu, Y., Kondo, I., Woods, C., Wegner, T. Cytogenet. Cell Genet. (1981) [Pubmed]
  16. Sex-chromosome linked gene expression in in-vitro produced bovine embryos. Peippo, J., Farazmand, A., Kurkilahti, M., Markkula, M., Basrur, P.K., King, W.A. Mol. Hum. Reprod. (2002) [Pubmed]
  17. Expression pattern of X-linked genes in sex chromosome aneuploid bovine cells. Basrur, P.K., Farazmand, A., Stranzinger, G., Graphodatskaya, D., Reyes, E.R., King, W.A. Chromosome Res. (2004) [Pubmed]
  18. Effect of speed of development on mRNA expression pattern in early bovine embryos cultured in vivo or in vitro. Gutiérrez-Adán, A., Rizos, D., Fair, T., Moreira, P.N., Pintado, B., de la Fuente, J., Boland, M.P., Lonergan, P. Mol. Reprod. Dev. (2004) [Pubmed]
  19. Assignment of chromosome rearrangements between X chromosomes of human and cattle by laser microdissection and Zoo-FISH. Rubes, J., Kubickova, S., Musilova, P., Amaral, M.E., Brunner, R.M., Goldammer, T. Chromosome Res. (2005) [Pubmed]
  20. Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage. Gutiérrez-Adán, A., Oter, M., Martínez-Madrid, B., Pintado, B., De La Fuente, J. Mol. Reprod. Dev. (2000) [Pubmed]
  21. Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutant colonies. Stamato, T.D., Richardson, E., Ianacone, J., MacLaren, R.A., Denko, N., Giaccia, A. Mutagenesis (1989) [Pubmed]
  22. alpha-crystallin protects glucose 6-phosphate dehydrogenase against inactivation by malondialdehyde. Ganea, E., Harding, J.J. Biochim. Biophys. Acta (2000) [Pubmed]
  23. Characteristics of parathyroid hormone-specific cyclic changes of glucose-6-phosphate dehydrogenase activity in the distal convoluted tubule of the guinea pig. Sakaguchi, K., Fukase, M., Kobayashi, I., Fujita, T. J. Bone Miner. Res. (1986) [Pubmed]
  24. Glucose 6-phosphate dehydrogenase of calf trabecular meshwork. Nguyen, K., Lee, D.A., Anderson, P.J., Epstein, D.L. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
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