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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IL3  -  interleukin 3 (colony-stimulating factor,...

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High impact information on IL3

  • Human recombinant interleukin 3 (IL-3) and/or granulocyte-macrophage colony-stimulating factor had no effect on CFU-E growth, while they markedly enhanced BFU-E growth [1].
  • We describe an in vitro culture system in which pulsing normal human cord blood leukocytes with interleukin-3 (IL-3) for 3-4 h followed by incubation in medium with fetal bovine serum generates a cell population that is predominately Fc epsilonRI positive between 14 and 28 days of culture [2].
  • Recombinant human IL-3 stimulated the growth of megakaryocyte progenitors [3].
 

Associations of IL3 with chemical compounds

  • Human megakaryocyte colony formation was observed in serum-free agar cultures with a medium containing deionized bovine serum albumin, iron-saturated transferrin, 2-mercaptoethanol, and recombinant human interleukin 3 (IL-3) [3].
 

Analytical, diagnostic and therapeutic context of IL3

  • They were then stimulated with kit ligand (KL), interleukin-3 (IL-3), and interleukin-1 beta (IL-1 beta) for 36 h either prior to cryopreservation or immediately after thawing [4].

References

  1. Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development. Sawada, K., Krantz, S.B., Dessypris, E.N., Koury, S.T., Sawyer, S.T. J. Clin. Invest. (1989) [Pubmed]
  2. The identification and characterization of umbilical cord blood-derived human basophils. Kepley, C.L., Pfeiffer, J.R., Schwartz, L.B., Wilson, B.S., Oliver, J.M. J. Leukoc. Biol. (1998) [Pubmed]
  3. Clonal growth of human megakaryocyte progenitors in serum-free cultures: effect of recombinant human interleukin 3. Teramura, M., Katahira, J., Hoshino, S., Motoji, T., Oshimi, K., Mizoguchi, H. Exp. Hematol. (1988) [Pubmed]
  4. Growth factor stimulation of cryopreserved CD34+ bone marrow cells intended for transplant: an in vitro study to determine optimal timing of exposure to early acting cytokines. Ratajczak, M.Z., Ratajczak, J., Kregenow, D.A., Gewirtz, A.M. Stem Cells (1994) [Pubmed]
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