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Gene Review

IL1B  -  interleukin 1, beta

Bos taurus

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Disease relevance of IL1B


High impact information on IL1B

  • Treatment of cultured bovine brain microvascular endothelial cells (BMECs) with interleukin 1 beta (IL-1 beta), an inflammatory cytokine, was shown to induce the accumulation of sulfoglucuronosyl paragloboside (SGPG), a glycolipid bearing the HNK-1 epitope [6].
  • Attachment of human lymphocytes to the IL-1 beta-activated BMEC cells could be blocked either by incubation of the human lymphocytes with an anti-L-selectin antibody or by application of an anti-SGPG antibody to the BMECs [6].
  • Treatment of BASMCs with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta) resulted in a significant increase in L-arginine transport (approximately 20%) and in the induction of NO release [7].
  • IL-1 beta is a proinflammatory cytokine secreted chiefly by monocytes and macrophages [8].
  • Infection induced the production of IL-1 beta, -6, and -8 mRNAs, and this effect was potentiated by IFN-gamma [2].

Biological context of IL1B

  • The cytogenetic position of PAX8 on BTA 11 and on its homologue OAR 3p lies in the region where the interleukin beta (IL1B) gene has been previously located, (BTA 11q22. 1-->q22.3 and OAR 3p25-->q26 respectively; Lòpez-Corrales et al., 1998) [9].
  • The results indicated that PAX8 as well as interleukin beta and interleukin alpha (IL1B and IL1A) genes detected on the human chromosome segment HSA 2q13-->q21 maintain a similar order and location in these three related species [9].
  • Bovine YAC and cosmid clones were used as FISH probes to determine the order (centromere to telomere) of four of these genes on OAR 2q, as well as the location of IL1B on OAR 3p [10].
  • The effect of LPS on TNF-alpha and IL-1 beta gene expression was dose dependent, and induction was observed at a concentration of 0.01 microgram/ml [3].
  • Bovine tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) cDNAs were generated by reverse transcription and then by PCR amplification from lipopolysaccharide (LPS)-stimulated alveolar macrophage RNA [3].

Anatomical context of IL1B


Associations of IL1B with chemical compounds


Regulatory relationships of IL1B

  • In all cultures of marrow from postmenopausal women, IL-1 beta suppressed IGFBP-3 secretion to either undetectable levels or levels between 11% and 35% of control [18].

Other interactions of IL1B

  • The level of HSP72 expression was not elevated by treatment with interleuken (IL)-1 alpha (10 ng ml-1), IL-1 beta (10 ng ml-1), tumour necrosis factor (TNF)-alpha (200 ng ml-1), or TNF-beta (200 ng ml-1) [19].
  • No statistical differences were observed in the expression of interferon-gamma, IL-1 beta, TNF-alpha, and GM-CSF among lepromatous, tuberculoid, and noninfected groups [20].
  • In particular, S. uberis infection was characterized by the sustained elevation of higher milk levels of IL-1 beta, IL-10, IL-12, IFN-gamma, and C5a, relative to S. marcescens infection [21].
  • CONCLUSIONS: Our data suggest that proteoglycan and collagen degradation are regulated through different mechanisms: IL-1 beta induces the synthesis of active enzymes that degrade proteoglycans, such as 'aggrecanase', and inactive proMMPs [22].
  • A positive correlation was observed between the concentrations of IL-1ra and IL-1 beta in the colostrum samples [23].

Analytical, diagnostic and therapeutic context of IL1B


  1. Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. Maliszewski, C.R., Baker, P.E., Schoenborn, M.A., Davis, B.S., Cosman, D., Gillis, S., Cerretti, D.P. Mol. Immunol. (1988) [Pubmed]
  2. Infection of bovine brain microvessel endothelial cells with Cowdria ruminantium elicits IL-1 beta, -6, and -8 mRNA production and expression of an unusual MHC class II DQ alpha transcript. Bourdoulous, S., Bensaid, A., Martinez, D., Sheikboudou, C., Trap, I., Strosberg, A.D., Couraud, P.O. J. Immunol. (1995) [Pubmed]
  3. Induction of inflammatory cytokines in bovine alveolar macrophages following stimulation with Pasteurella haemolytica lipopolysaccharide. Yoo, H.S., Maheswaran, S.K., Lin, G., Townsend, E.L., Ames, T.R. Infect. Immun. (1995) [Pubmed]
  4. Heparin fails to potentiate the effects of IL-1 beta-mediated bone resorption of fetal rat long bones in vitro. Panagakos, F.S., Jandinski, J.J., Feder, L., Kumar, S. Biochimie (1995) [Pubmed]
  5. High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. de Mattei, M., Pellati, A., Pasello, M., de Terlizzi, F., Massari, L., Gemmati, D., Caruso, A. Osteoarthr. Cartil. (2002) [Pubmed]
  6. Interleukin 1 beta up-regulates the expression of sulfoglucuronosyl paragloboside, a ligand for L-selectin, in brain microvascular endothelial cells. Kanda, T., Yamawaki, M., Ariga, T., Yu, R.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Differential regulation of L-arginine transport and nitric oxide production by vascular smooth muscle and endothelium. Durante, W., Liao, L., Iftikhar, I., O'Brien, W.E., Schafer, A.I. Circ. Res. (1996) [Pubmed]
  8. Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production. O'Brien, J.M., Wewers, M.D., Moore, S.A., Allen, J.N. J. Immunol. (1995) [Pubmed]
  9. Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8. Lòpez-Corrales, N.L., Sonstegard, T.S., Smith, T.P. Cytogenet. Cell Genet. (1999) [Pubmed]
  10. Comparative gene mapping: cytogenetic localization of PROC, EN1, ALPI, TNP1, and IL1B in cattle and sheep reveals a conserved rearrangement relative to the human genome. Lòpez-Corrales, N.L., Sonstegard, T.S., Smith, T.P. Cytogenet. Cell Genet. (1998) [Pubmed]
  11. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. Selmaj, K.W., Farooq, M., Norton, W.T., Raine, C.S., Brosnan, C.F. J. Immunol. (1990) [Pubmed]
  12. Interleukin-1 inhibits human thyroid carcinoma cell growth. Kimura, H., Yamashita, S., Namba, H., Tominaga, T., Tsuruta, M., Yokoyama, N., Izumi, M., Nagataki, S. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  13. Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha: modulation of these cellular responses by interleukin-6 and platelet-derived growth factor. Smith, R.J., Justen, J.M., Ulrich, R.G., Lund, J.E., Sam, L.M. Clin. Immunol. Immunopathol. (1992) [Pubmed]
  14. Functional studies of bovine alveolar neutrophils elicited with recombinant bovine IL-1 beta. Heidel, J.R., Sassenfeld, H.M., Maliszewdki, C.R., Silflow, R.M., Baker, P.E., Taylor, S.M., Leid, R.W. J. Immunol. (1990) [Pubmed]
  15. Endothelial cells regulate proximal tubule epithelial cell sodium transport. Linas, S.L., Repine, J.E. Kidney Int. (1999) [Pubmed]
  16. Detection of bovine interleukin 1 alpha and interleukin 1 beta gene expression by reverse transcription-polymerase chain reaction. Ito, T., Kodama, M. Vet. Immunol. Immunopathol. (1994) [Pubmed]
  17. Endothelial cells inhibit NO generation by vascular smooth muscle cells. Role of transforming growth factor-beta. López Farré, A., Mosquera, J.R., Sánchez de Miguel, L., Millás, I., de Frutos, T., Montón, M., Sierra, M.P., Riesco, A., Casado, S. Arterioscler. Thromb. Vasc. Biol. (1996) [Pubmed]
  18. Effects of age and estrogen status on the skeletal IGF regulatory system. Studies with human marrow. Rosen, C.J., Verault, D., Steffens, C., Cheleuitte, D., Glowacki, J. Endocrine (1997) [Pubmed]
  19. Constitutive and inducible expression of heat shock protein HSP72 in oligodendrocytes in culture. Satoh, J., Kim, S.U. Neuroreport (1995) [Pubmed]
  20. Inflammatory cytokine gene expression in different types of granulomatous lesions during asymptomatic stages of bovine paratuberculosis. Tanaka, S., Sato, M., Onitsuka, T., Kamata, H., Yokomizo, Y. Vet. Pathol. (2005) [Pubmed]
  21. Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis. Bannerman, D.D., Paape, M.J., Goff, J.P., Kimura, K., Lippolis, J.D., Hope, J.C. Vet. Res. (2004) [Pubmed]
  22. Matrix degradation by chondrocytes cultured in alginate: IL-1 beta induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation. Beekman, B., Verzijl, N., de Roos, J.A., TeKoppele, J.M. Osteoarthr. Cartil. (1998) [Pubmed]
  23. Detection of cytokines in bovine colostrum. Hagiwara, K., Kataoka, S., Yamanaka, H., Kirisawa, R., Iwai, H. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  24. Cloning bovine cytokine cDNA fragments and measuring bovine cytokine mRNA using the reverse transcription-polymerase chain reaction. Hutchinson, L.E., Stevens, M.G., Olsen, S.C. Vet. Immunol. Immunopathol. (1994) [Pubmed]
  25. Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1-stimulated cartilage erosion and chondrocyte responsiveness. Smith, R.J., Chin, J.E., Sam, L.M., Justen, J.M. Arthritis Rheum. (1991) [Pubmed]
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