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Gene Review

GPX3  -  glutathione peroxidase 3 (plasma)

Bos taurus

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Disease relevance of GPX3


High impact information on GPX3

  • The high levels of expression for GPx-3 in the isthmus were in contrast to expression of GPx-1 and GPx-2, which occurred mostly in the ampulla and infundibulum of the oviduct [2].
  • Therefore, we have analyzed the mechanism of production of pGPx in adipocytes [3].
  • The expression of pGPx and C/EBPdelta increases during adipogenesis, with dexamethasone being the main effector of these genes [3].
  • The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells [3].
  • Plasma glutathione peroxidase was correlated positively to Se intake but negatively to SCC [4].


  1. Selenium effects on glutathione peroxidase and the immune response of stressed calves challenged with Pasteurella hemolytica. Stabel, J.R., Spears, J.W., Brown, T.T., Brake, J. J. Anim. Sci. (1989) [Pubmed]
  2. Antioxidant defenses are modulated in the cow oviduct during the estrous cycle. Lapointe, J., Bilodeau, J.F. Biol. Reprod. (2003) [Pubmed]
  3. Mechanism of plasma glutathione peroxidase production in bovine adipocytes. Yamasaki, T., Tahara, K., Takano, S., Inoue-Murayama, M., Rose, M.T., Minashima, T., Aso, H., Ito, S. Cell Tissue Res. (2006) [Pubmed]
  4. Relationships among selenium, vitamin E, and mammary gland health in commercial dairy herds. Weiss, W.P., Hogan, J.S., Smith, K.L., Hoblet, K.H. J. Dairy Sci. (1990) [Pubmed]
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