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Gene Review

GPX3  -  glutathione peroxidase 3 (plasma)

Homo sapiens

Synonyms: Extracellular glutathione peroxidase, GPXP, GPx-3, GPx-P, GSHPx-3, ...
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Disease relevance of GPX3


Psychiatry related information on GPX3


High impact information on GPX3


Chemical compound and disease context of GPX3


Biological context of GPX3


Anatomical context of GPX3


Associations of GPX3 with chemical compounds


Regulatory relationships of GPX3


Other interactions of GPX3


Analytical, diagnostic and therapeutic context of GPX3


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  2. Plasma glutathione peroxidase activity as a potential indicator of hypoxic stress in breath-hold diving. Rousseau, A.S., Richer, C., Richard, M.J., Favier, A., Margaritis, I. Aviation, space, and environmental medicine. (2006) [Pubmed]
  3. Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa. Mörk, H., al-Taie, O.H., Bähr, K., Zierer, A., Beck, C., Scheurlen, M., Jakob, F., Köhrle, J. Nutrition and cancer. (2000) [Pubmed]
  4. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Lee, O.J., Schneider-Stock, R., McChesney, P.A., Kuester, D., Roessner, A., Vieth, M., Moskaluk, C.A., El-Rifai, W. Neoplasia (2005) [Pubmed]
  5. Glutathione peroxidase levels throughout normal pregnancy and in pre-eclampsia. Funai, E.F., MacKenzie, A., Kadner, S.S., Roque, H., Lee, M.J., Kuczynski, E. J. Matern. Fetal. Neonatal. Med. (2002) [Pubmed]
  6. Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Yu, Y.P., Yu, G., Tseng, G., Cieply, K., Nelson, J., Defrances, M., Zarnegar, R., Michalopoulos, G., Luo, J.H. Cancer Res. (2007) [Pubmed]
  7. Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type--place of the extracellular glutathione peroxidase. Ceballos-Picot, I., Merad-Boudia, M., Nicole, A., Thevenin, M., Hellier, G., Legrain, S., Berr, C. Free Radic. Biol. Med. (1996) [Pubmed]
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  9. Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Gladyshev, V.N., Stadtman, T.C., Hatfield, D.L., Jeang, K.T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. An RNA-binding protein recognizes a mammalian selenocysteine insertion sequence element required for cotranslational incorporation of selenocysteine. Lesoon, A., Mehta, A., Singh, R., Chisolm, G.M., Driscoll, D.M. Mol. Cell. Biol. (1997) [Pubmed]
  11. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Chu, F.F., Esworthy, R.S., Doroshow, J.H., Doan, K., Liu, X.F. Blood (1992) [Pubmed]
  12. Antihuman plasma glutathione peroxidase antibodies: immunologic investigations to determine plasma glutathione peroxidase protein and selenium content in plasma. Avissar, N., Whitin, J.C., Allen, P.Z., Palmer, I.S., Cohen, H.J. Blood (1989) [Pubmed]
  13. Acetaminophen toxicity. Opposite effects of two forms of glutathione peroxidase. Mirochnitchenko, O., Weisbrot-Lefkowitz, M., Reuhl, K., Chen, L., Yang, C., Inouye, M. J. Biol. Chem. (1999) [Pubmed]
  14. Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis. Tham, D.M., Whitin, J.C., Cohen, H.J. Pediatr. Res. (2002) [Pubmed]
  15. Modified expression of plasma glutathione peroxidase and manganese superoxide dismutase in human renal cell carcinoma. Sarto, C., Frutiger, S., Cappellano, F., Sanchez, J.C., Doro, G., Catanzaro, F., Hughes, G.J., Hochstrasser, D.F., Mocarelli, P. Electrophoresis (1999) [Pubmed]
  16. Extracellular glutathione peroxidase and ascorbic acid in aqueous humor and serum of patients operated on for cataract. Haung, W., Koralewska-Makár, A., Bauer, B., Akesson, B. Clin. Chim. Acta (1997) [Pubmed]
  17. Coordinately up-regulated genes in ovarian cancer. Hough, C.D., Cho, K.R., Zonderman, A.B., Schwartz, D.R., Morin, P.J. Cancer Res. (2001) [Pubmed]
  18. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. Chu, F.F. Cytogenet. Cell Genet. (1994) [Pubmed]
  19. A haplotype-based test of association using data from cohort and nested case-control epidemiologic studies. Chen, J., Peters, U., Foster, C., Chatterjee, N. Hum. Hered. (2004) [Pubmed]
  20. Partial sequence of human plasma glutathione peroxidase and immunologic identification of milk glutathione peroxidase as the plasma enzyme. Avissar, N., Slemmon, J.R., Palmer, I.S., Cohen, H.J. J. Nutr. (1991) [Pubmed]
  21. Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye. Martín-Alonso, J.M., Ghosh, S., Coca-Prados, M. J. Biochem. (1993) [Pubmed]
  22. Glutathione peroxidase (GPX) activity in seminal plasma of healthy and infertile males. Giannattasio, A., De Rosa, M., Smeraglia, R., Zarrilli, S., Cimmino, A., Di Rosario, B., Ruggiero, R., Colao, A., Lombardi, G. J. Endocrinol. Invest. (2002) [Pubmed]
  23. Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. Tham, D.M., Whitin, J.C., Kim, K.K., Zhu, S.X., Cohen, H.J. Am. J. Physiol. (1998) [Pubmed]
  24. Selenium and endocrine systems. Beckett, G.J., Arthur, J.R. J. Endocrinol. (2005) [Pubmed]
  25. Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase. Maddipati, K.R., Marnett, L.J. J. Biol. Chem. (1987) [Pubmed]
  26. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke. Comhair, S.A., Thomassen, M.J., Erzurum, S.C. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  27. Extracellular glutathione peroxidase mRNA and protein in human cell lines. Avissar, N., Kerl, E.A., Baker, S.S., Cohen, H.J. Arch. Biochem. Biophys. (1994) [Pubmed]
  28. Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase. Odenwaller, R., Maddipati, K.R., Marnett, L.J. J. Biol. Chem. (1992) [Pubmed]
  29. Structure, gene expression, and evolution of primate glutathione peroxidases. Fukuhara, R., Kageyama, T. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  30. Human placenta makes extracellular glutathione peroxidase and secretes it into maternal circulation. Avissar, N., Eisenmann, C., Breen, J.G., Horowitz, S., Miller, R.K., Cohen, H.J. Am. J. Physiol. (1994) [Pubmed]
  31. Expression pattern of gastrointestinal selenoproteins--targets for selenium supplementation. Mörk, H., Lex, B., Scheurlen, M., Dreher, I., Schütze, N., Köhrle, J., Jakob, F. Nutrition and cancer. (1998) [Pubmed]
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