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Gene Review:

NPFF - neuropeptide FF-amide peptide precursor

Bos taurus

Zhu, J. et al., Majane, E.A. et al., Crespo, M. et al., Aarnisalo, A.A. et al.

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Psychiatry related information on NPFF

Furthermore, there have been studies indicating that NPFF may participate in the regulation of pain threshold in the spinal cord [1].

High impact information on NPFF

Neuropeptide-FF (NPFF) is unevenly distributed in the central nervous system, with the highest concentrations in posterior pituitary and spinal cord [2].
In the rat pituitary, NPFF is found exclusively in the neural lobe, where it is localized in nerve terminals and fibers, indicating the hypothalamus as a possible source of the neural lobe NPFF [2].
The present experiments, using an in vitro superfusion of an isolated whole rat spinal cord, demonstrated that high concentrations of KCl or substance P caused a release of NPFF immunoreactive material (IR) from the spinal cord into the perfusion medium in a calcium-dependent manner [1].
Neuropeptide FF (NPFF) is highly localized in the dorsal spinal cords where there are also specific NPFF binding sites [1].
The neuropeptide FF (NPFF) is a member of the RFamide related peptides (FaRPs) that share the dipeptide Arg-Phe-NH2 at their C-terminal [3].

Associations of NPFF with chemical compounds

NPAF is an octadecapeptide isolated from the bovine brain together with neuropeptide FF (NPFF) [4].
In view of the role of substance P (1-11) and substance P (1-7) in sensory transmission, the results of this study further support the role of NPFF in the modulation of antinociception in the spinal cord [1].

Analytical, diagnostic and therapeutic context of NPFF

The released NPFF-IR was analyzed by an HPLC study and found to consist of NPFF and other minor immunoreactive peptides [1].

References

Release of neuropeptide FF (FLFQPQRF-NH2) from rat spinal cord. Zhu, J., Jhamandas, K., Yang, H.Y. Brain Res. (1992) [Pubmed]
Origin of neurohypophyseal neuropeptide-FF (FLFQPQRF-NH2). Majane, E.A., Zhu, J., Aarnisalo, A.A., Panula, P., Yang, H.Y. Endocrinology (1993) [Pubmed]
Comparative analysis of neuropeptide FF-like immunoreactivity in the brain of anuran (Rana perezi, Xenopus laevis) and urodele (Pleurodeles waltl) amphibians. Crespo, M., Moreno, N., López, J.M., González, A. J. Chem. Neuroanat. (2003) [Pubmed]
Peptide GEGLSS-like immunoreactivity in the rat central nervous system. Aarnisalo, A.A., Karhunen, T., Vanhatalo, S., Panula, P. Brain Res. Bull. (1997) [Pubmed]

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NPFF	Homo sapiens
NPFF	Macaca mulatta
Npff	Mus musculus
NPFF	Pan troglodytes
Npff	Rattus norvegicus

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