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MeSH Review

Pain Threshold

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Disease relevance of Pain Threshold


Psychiatry related information on Pain Threshold


High impact information on Pain Threshold


Chemical compound and disease context of Pain Threshold

  • We propose that in diabetes, generally, the pain threshold is adequately maintained, despite the antagonistic effect of glucose, partly due to a compensatory increased secretion of endogenous opioid peptides [15].
  • Hydroxychloroquine and pain thresholds [16].
  • As a functional corollary to alterations in neurochemical parameters, we observed significant disulfiram-induced increases in pain thresholds, potentiated by capsaicin treatment [17].
  • OBJECTIVES: The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception [18].
  • METHODS: This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs [19].

Biological context of Pain Threshold


Anatomical context of Pain Threshold


Gene context of Pain Threshold

  • No overt behavioral differences were apparent between Folh1-/- mice and wild-type littermates, with respect to their overall performance in locomotion, coordination, pain threshold, cognition and psychiatric behavioral paradigms [28].
  • Peripheral CRF reduced pain threshold to colonic distention and increased colonic motility in humans [29].
  • Despite the increase in CGRP in GDNF-treated rats, there was no increase in thermal or mechanical pain sensitivity, while NGF-treated animals showed significant decreases in pain thresholds [30].
  • These studies demonstrate that, in contrast to the highly significant role for Nav1.7 in determining inflammatory pain thresholds, the development of neuropathic pain does not require the presence of either Nav1.7 or Nav1.8 alone or in combination [31].
  • Double knockouts of both Nav1.7 and Nav1.8 also develop normal levels of neuropathic pain, despite a lack of inflammatory pain symptoms and altered mechanical and thermal acute pain thresholds [31].

Analytical, diagnostic and therapeutic context of Pain Threshold


  1. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Song, G.H., Leng, P.H., Gwee, K.A., Moochhala, S.M., Ho, K.Y. Gut (2005) [Pubmed]
  2. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. LaMotte, R.H., Lundberg, L.E., Torebjörk, H.E. J. Physiol. (Lond.) (1992) [Pubmed]
  3. Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Gibson, S.J., Littlejohn, G.O., Gorman, M.M., Helme, R.D., Granges, G. Pain (1994) [Pubmed]
  4. Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats. Tarrerias, A.L., Millecamps, M., Alloui, A., Beaughard, C., Kemeny, J.L., Bourdu, S., Bommelaer, G., Eschalier, A., Dapoigny, M., Ardid, D. Pain (2002) [Pubmed]
  5. Pressure pain thresholds in patients with craniomandibular disorders before and after treatment with acupuncture and occlusal splint therapy: a controlled clinical study. List, T., Helkimo, M., Karlsson, R. Journal of orofacial pain. (1993) [Pubmed]
  6. Is systemically administered oxytocin an analgesic in rats? Xu, X.J., Wiesenfeld-Hallin, Z. Pain (1994) [Pubmed]
  7. An analgesic effect of enkephalinase inhibition is modulated by monoamine oxidase-B and REM sleep deprivations. Ukponmwan, O.E., Rupreht, J., Dzoljic, M. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]
  8. Pain modulation role of melatonin in eating disorders. Papezová, H., Yamamotová, A., Nedvídková, J. Eur. Psychiatry (2001) [Pubmed]
  9. Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. Barone, R., Lempereur, L., Anastasi, M., Parano, E., Pavone, P. Neuropediatrics. (2005) [Pubmed]
  10. Are there psychologic predictors of treatment outcome in temporomandibular joint pain and dysfunction? Schnurr, R.F., Rollman, G.B., Brooke, R.I. Oral Surg. Oral Med. Oral Pathol. (1991) [Pubmed]
  11. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Willert, R.P., Woolf, C.J., Hobson, A.R., Delaney, C., Thompson, D.G., Aziz, Q. Gastroenterology (2004) [Pubmed]
  12. Gastric distention correlates with activation of multiple cortical and subcortical regions. Ladabaum, U., Minoshima, S., Hasler, W.L., Cross, D., Chey, W.D., Owyang, C. Gastroenterology (2001) [Pubmed]
  13. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Mitrovic, I., Margeta-Mitrovic, M., Bader, S., Stoffel, M., Jan, L.Y., Basbaum, A.I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  14. Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. Zimmer, A., Zimmer, A.M., Baffi, J., Usdin, T., Reynolds, K., König, M., Palkovits, M., Mezey, E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  15. Effect of hyperglycemia on pain perception and on efficacy of morphine analgesia in rats. Raz, I., Hasdai, D., Seltzer, Z., Melmed, R.N. Diabetes (1988) [Pubmed]
  16. Hydroxychloroquine and pain thresholds. Middleton, G.D., McFarlin, J.E., Lipsky, P.E. Arthritis Rheum. (1995) [Pubmed]
  17. Disulfiram administration affects substance P-like immunoreactive and monoaminergic neural systems in rodent brain. Marchand, J.E., Hershman, K., Kumar, M.S., Thompson, M.L., Kream, R.M. J. Biol. Chem. (1990) [Pubmed]
  18. Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study. Sheps, D.S., McMahon, R.P., Light, K.C., Maixner, W., Pepine, C.J., Cohen, J.D., Goldberg, A.D., Bonsall, R., Carney, R., Stone, P.H., Sheffield, D., Kaufmann, P.G. J. Am. Coll. Cardiol. (1999) [Pubmed]
  19. Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. Burian, M., Tegeder, I., Seegel, M., Geisslinger, G. Clin. Pharmacol. Ther. (2003) [Pubmed]
  20. Dexamethasone prevents the induction of COX-2 mRNA and prostaglandins in the lumbar spinal cord following intraplantar FCA in parallel with inhibition of oedema. Hay, C.H., de Belleroche, J.S. Neuropharmacology (1998) [Pubmed]
  21. Mechanisms of pain relief by vibration and movement. Kakigi, R., Shibasaki, H. J. Neurol. Neurosurg. Psychiatr. (1992) [Pubmed]
  22. Effects of tizanidine administration on precipitated opioid withdrawal signs in rats. Pinelli, A., Trivulzio, S., Spezia, R. Drug and alcohol dependence. (1998) [Pubmed]
  23. Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat. Walker, D., Carrington, A., Cannan, S.A., Sawicki, D., Sredy, J., Boulton, A.J., Malik, R.A. J. Anat. (1999) [Pubmed]
  24. Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery. Sterling, M., Jull, G., Vicenzino, B., Kenardy, J. Pain (2003) [Pubmed]
  25. Sex differences in temporal characteristics of descending inhibitory control: an evaluation using repeated bilateral experimental induction of muscle pain. Ge, H.Y., Madeleine, P., Arendt-Nielsen, L. Pain (2004) [Pubmed]
  26. Effects of PRES baroreceptor stimulation on thermal and mechanical pain threshold in borderline hypertensives and normotensives. Rau, H., Brody, S., Larbig, W., Pauli, P., Vöhringer, M., Harsch, B., Kröling, P., Birbaumer, N. Psychophysiology. (1994) [Pubmed]
  27. Pain, tenderness, wheal and flare induced by substance-P, bradykinin and 5-hydroxytryptamine in humans. Jensen, K., Tuxen, C., Pedersen-Bjergaard, U., Jansen, I. Cephalalgia : an international journal of headache. (1991) [Pubmed]
  28. Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury. Bacich, D.J., Wozniak, K.M., Lu, X.C., O'Keefe, D.S., Callizot, N., Heston, W.D., Slusher, B.S. J. Neurochem. (2005) [Pubmed]
  29. CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. Taché, Y., Martinez, V., Wang, L., Million, M. Br. J. Pharmacol. (2004) [Pubmed]
  30. Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo. Ramer, M.S., Bradbury, E.J., Michael, G.J., Lever, I.J., McMahon, S.B. Eur. J. Neurosci. (2003) [Pubmed]
  31. Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8. Nassar, M.A., Levato, A., Stirling, L.C., Wood, J.N. Molecular pain [electronic resource] (2005) [Pubmed]
  32. Anxiety and pain: epinephrine-induced hyperalgesia and attentional influences. Janssen, S.A., Arntz, A., Bouts, S. Pain (1998) [Pubmed]
  33. Pharmacological modulations on the nociceptive flexion reflex in man. Willer, J.C., Bathien, N. Pain (1977) [Pubmed]
  34. Reliability and validity of verbal descriptor scales of painfulness. Gracely, R.H., Dubner, R. Pain (1987) [Pubmed]
  35. Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Galeotti, N., Bartolini, A., Calvani, M., Nicolai, R., Ghelardini, C. Neuropharmacology (2004) [Pubmed]
  36. The role of opioid receptors in diabetes and hyperglycemia-induced changes in pain threshold in the rat. Akunne, H.C., Soliman, K.F. Psychopharmacology (Berl.) (1987) [Pubmed]
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