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Gene Review

SDHA  -  succinate dehydrogenase complex, subunit A...

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High impact information on SDHA

  • Iron-sulfur clusters S-1, S-2, and S-3 were assembled also when the covalently bound flavin in the Fp subunit was absent [1].
  • Iron-sulfur cluster S-1 was found to be assembled in soluble succinate dehydrogenase subunits in the cytoplasm, but only if full-length Fp polypeptides and relatively large fragments of Ip polypeptides were present [1].
  • Furthermore, the Ascaris Fp subunit was shown to contain two regions exhibiting striking sequence similarity to the segments that have been predicted to interact noncovalently with the AMP moiety of FAD in bacterial Fp subunits [2].
  • Mapping of the SDHA locus to bovine chromosome 20 [3].

Associations of SDHA with chemical compounds

  • Succinate dehydrogenase is a conserved membrane-bound enzyme consisting of two nonidentical subunits: a flavo iron-sulfur protein (Fp) subunit, containing a covalently bound flavin, and an iron-sulfur protein (Ip) subunit [1].
  • The flavoprotein (Fp) subunit of mitochondrial complex II contains covalently bound FAD as a prosthetic group [2].


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