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Gene Review

Sdha  -  succinate dehydrogenase complex, subunit A...

Rattus norvegicus

Synonyms: Flavoprotein subunit of complex II, Fp
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Disease relevance of Sdha

  • After a tetanus with glucose present the PN of the anaerobic muscle, but not the Fp underwent a substantial transient oxidation [1].

High impact information on Sdha

  • The Fp subunit gene is duplicated in the human genome (3q29; 5p15), with only the gene on chromosome 5 expressed in human-hamster somatic cell hybrids [2].
  • Since Fp and PN are near oxidation-reduction equilibrium, the ratio of the two fluorescence intensities, suitably normalized, approximates the oxidation-reduction ratio of oxidized flavoprotein/reduced pyridine nucleotide [3].
  • The recording of oxidation-reduction-related fluorescence signals of oxidized flavoprotein (Fp) and reduced pyridine nucleotide (PN) from isolated mitochondria at temperatures below -80 degrees C can be accompanished with a high degree of accuracy and a wide dynamic range [3].
  • Moreover, NAD(P)H and flavoprotein (Fp) fluorescence changes were observed to rapidly occur following MIBG addition in vitro [4].
  • This is determined from the redox ratio changes derived from the intrinsic oxidized flavoprotein (Fp) and reduced pyridine nucleotide (PN) [i.e., reduced nicotinamide adenine dinucleotide (NADH)] fluorescence signals observed using a cryoimager [5].

Biological context of Sdha

  • Due to the partial ischaemia developed, oscillations in the level of intramitochondrial pyridine nucleotides (NADH) as well as flavoproteins (Fp) were recorded from the brain by monitoring the fluorescence of these respiratory chain components [6].

Anatomical context of Sdha

  • The normalized ratio of PN to flavoproteins (Fp) in the lens epithelium increased from 0.96 +/- 0.12 in the normal state to 1.48 +/- 0.30 2 weeks after diabetes induction [7].
  • Using a time-sharing fluorometer-reflectometer, pyridine nucleotide (NADH) and flavoprotein (Fp) fluorescence, as well as reflected light at the excitation wavelength, were measured and correlated with the electrical activity of an awake cerebral cortex [8].

Associations of Sdha with chemical compounds


Analytical, diagnostic and therapeutic context of Sdha

  • Changes in intracellular pH measured with 31P-NMR, in vivo, precede the changes in fluorescence of NAD(P)H and Fp obtained with frozen sections of tumor [4].
  • The autofluorescence of reduced pyridine nucleotides (PN) and oxidized flavoproteins (Fp) in the rat lens epithelium was measured noninvasively as a function of time using redox fluorometry [9].


  1. A cytoplasmic component of pyridine nucleotide fluorescence in rat diaphragm: evidence from comparisons with flavoprotein fluorescence. Paddle, B.M. Pflugers Arch. (1985) [Pubmed]
  2. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Bourgeron, T., Rustin, P., Chretien, D., Birch-Machin, M., Bourgeois, M., Viegas-Péquignot, E., Munnich, A., Rötig, A. Nat. Genet. (1995) [Pubmed]
  3. Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. Chance, B., Schoener, B., Oshino, R., Itshak, F., Nakase, Y. J. Biol. Chem. (1979) [Pubmed]
  4. MIBG inhibits respiration: potential for radio- and hyperthermic sensitization. Biaglow, J.E., Manevich, Y., Leeper, D., Chance, B., Dewhirst, M.W., Jenkins, W.T., Tuttle, S.W., Wroblewski, K., Glickson, J.D., Stevens, C., Evans, S.M. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  5. Redox ratio of mitochondria as an indicator for the response of photodynamic therapy. Zhang, Z., Blessington, D., Li, H., Busch, T.M., Glickson, J., Luo, Q., Chance, B., Zheng, G. Journal of biomedical optics. (2004) [Pubmed]
  6. Oscillations of cortical oxidative metabolism and microcirculation in the ischaemic brain. Mayevsky, A., Ziv, I. Neurol. Res. (1991) [Pubmed]
  7. Lens redox fluorometry: pyridine nucleotide fluorescence and analysis of diabetic lens. Tsubota, K., Krauss, J.M., Kenyon, K.R., Laing, R.A., Miglior, S., Cheng, H.M. Exp. Eye Res. (1989) [Pubmed]
  8. Brain energy metabolism of the conscious rat exposed to various physiological and pathological situations. Mayevsky, A. Brain Res. (1976) [Pubmed]
  9. Glycolytic oscillation and effect of metabolic inhibitor on rat lens. Tsubota, K., Laing, R.A. Jpn. J. Ophthalmol. (1992) [Pubmed]
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