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Gene Review

Sdha  -  succinate dehydrogenase complex, subunit A...

Mus musculus

Synonyms: 1500032O14Rik, 2310034D06Rik, 4921513A11, C81073, FP, ...
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Disease relevance of Sdha

  • The steady-state concentration of FP mRNA was inversely correlated with PGF(2alpha) levels in normal and hyperplastic epidermis and in papillomas, indicating that FP mRNA expression is regulated by this eicosanoid [1].

High impact information on Sdha

  • The availability of this group of transcription factors may be reduced in c14CoS hepatocytes and therefore caused depressed transcription rates of their target genes such as those encoding albumin and alpha FP [2].
  • Serial IOP measurements were also performed after topical bimatoprost in a separate generation of homozygous FP-knockout mice and wild-type littermate control animals (n = 4 per group) [3].
  • The lack of an IOP response in the FP-knockout mice was not a consequence of blood-aqueous barrier breakdown, as there was no significant difference in aqueous humor protein concentration between treated and fellow eyes [3].
  • Reverse transcription polymerase chain reaction (RT-PCR) and Northern blot analysis was used to determine the level of expression of prostaglandin F(2alpha) (FP) receptor mRNA in various mouse tissues, including normal, hyperplastic and neoplastic mouse epidermis [1].
  • At progesterone-delayed term birth on GD 19.3, even though tissue PGF(2alpha) concentrations were at the same high levels observed at normal term birth, CX-43 and FP mRNA levels were lower than those at normal term birth, thereby possibly contributing to the delay of birth [4].

Biological context of Sdha

  • Reactivity against a TSHr-like protein may be the first event leading to ophthalmopathy in humans with TAO and experimental mice and eye muscle damage may result from autoimmunity against G2s and Fp as a result of "antigen spreading" [5].

Anatomical context of Sdha

  • None of the transfer mice had serum antibodies against G2s, Fp or TSHr but their orbital tissue showed the same degree of mast cell infiltration as primary mice [5].
  • The finding of negative anti-G2s but positive anti-Fp antibodies in some CD-1 mice suggests that eye muscle damage and Fp release must have been mediated by T lymphocytes, rather than antibodies, targeting G2s or some other as yet unidentified cell membrane antigen [5].

Associations of Sdha with chemical compounds

  • Increased consumption of energy and O2 led to a concomitant reduction of cytochrome aa3 and oxidation of Fp [6].
  • Sera from the great majority of experimental mice contained antibodies against a G2s fusion protein and the flavoprotein (Fp) subunit of mitochondrial succinate dehydrogenase, the "64 kDa protein", with the greatest levels being found at sacrifice (17 wk) [5].


  1. Expression of PGF(2alpha) receptor mRNA in normal, hyperplastic and neoplastic skin. Müller, K., Krieg, P., Marks, F., Fürstenberger, G. Carcinogenesis (2000) [Pubmed]
  2. Transcriptional control in hepatocytes of normal and c14CoS albino deletion mice. Tönjes, R.R., Xanthopoulos, K.G., Darnell, J.E., Paul, D. EMBO J. (1992) [Pubmed]
  3. Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. Crowston, J.G., Lindsey, J.D., Morris, C.A., Wheeler, L., Medeiros, F.A., Weinreb, R.N. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  4. Mouse placental prostaglandins are associated with uterine activation and the timing of birth. Cook, J.L., Shallow, M.C., Zaragoza, D.B., Anderson, K.I., Olson, D.M. Biol. Reprod. (2003) [Pubmed]
  5. Experimental model for ophthalmopathy in BALB/c and outbred (CD-1) mice genetically immunized with G2s and the thyrotropin receptor. Yamada, M., Li, A.W., West, K.A., Chang, C.H., Wall, J.R. Autoimmunity (2002) [Pubmed]
  6. Regulation of cellular respiration in myoglobin-deficient mouse heart. Liimatta, E.V., Gödecke, A., Schrader, J., Hassinen, I.E. Mol. Cell. Biochem. (2004) [Pubmed]
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