The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CCNA2  -  cyclin A2

Bos taurus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on CCNA2

  • Mutation of the activating transcription factor (ATF) consensus sequence at bp -80 to -73 of the cyclin A promoter decreased its activity, indicating the critical role of the ATF site [1].
  • Cyclin A2 levels were higher in neonatal versus adult WT or transgenic mouse aortas [2].
  • We also demonstrate that deletion of, or point mutations, in the cyclin A homologue of the 10-residue "destruction box," previously described in cyclin B (Glotzer et al., 1991) abolish cyclin proteolysis at the transition from M-phase to interphase [3].
  • In addition, we find that E1 shuttling occurs in S phase, when cyclin A-Cdk2 is activated [4].
  • Notably, doxazosin inhibited phosphorylation of Rb and expression of cyclin A, both of which are necessary for cell cycle progression [5].
 

Anatomical context of CCNA2

  • Functionally novel tumor necrosis factor-alpha-modulated CHR-binding protein mediates cyclin A transcriptional repression in vascular endothelial cells [6].
 

Other interactions of CCNA2

  • An inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation, while a constant lengthening was observed for cyclin B1, occurring during the first 12 hr of incubation [7].
  • Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids [8].
 

Analytical, diagnostic and therapeutic context of CCNA2

  • The binding of cyclin A to p34cdc2 and p32cdk2 and the protein kinase activity of the complexes has been measured by cell-free translation of the corresponding mRNA in extracts of frog eggs, followed by immunoprecipitation [3].

References

  1. The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Yoshizumi, M., Hsieh, C.M., Zhou, F., Tsai, J.C., Patterson, C., Perrella, M.A., Lee, M.E. Mol. Cell. Biol. (1995) [Pubmed]
  2. B-Myb represses elastin gene expression in aortic smooth muscle cells. Hofmann, C.S., Wang, X., Sullivan, C.P., Toselli, P., Stone, P.J., McLean, S.E., Mecham, R.P., Schreiber, B.M., Sonenshein, G.E. J. Biol. Chem. (2005) [Pubmed]
  3. Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. Kobayashi, H., Stewart, E., Poon, R., Adamczewski, J.P., Gannon, J., Hunt, T. Mol. Biol. Cell (1992) [Pubmed]
  4. Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase. Hsu, C.Y., Mechali, F., Bonne-Andrea, C. J. Virol. (2007) [Pubmed]
  5. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. Austin, P.F., Cook, B.L., Niederhoff, R.A., Manson, S.R., Coplen, D.E., Weintraub, S.J. J. Urol. (2004) [Pubmed]
  6. Functionally novel tumor necrosis factor-alpha-modulated CHR-binding protein mediates cyclin A transcriptional repression in vascular endothelial cells. Kishore, R., Spyridopoulos, I., Luedemann, C., Losordo, D.W. Circ. Res. (2002) [Pubmed]
  7. Effects of polyadenylation inhibition on meiosis progression in relation to the polyadenylation status of cyclins A2 and B1 during in vitro maturation of bovine oocytes. Traverso, J.M., Donnay, I., Lequarre, A.S. Mol. Reprod. Dev. (2005) [Pubmed]
  8. Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids. Nixon, C., Chambers, G., Ellsmore, V., Campo, M.S., Burr, P., Argyle, D.J., Reid, S.W., Nasir, L. Cancer Lett. (2005) [Pubmed]
 
WikiGenes - Universities