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Gene Review

CDK2  -  cyclin-dependent kinase 2

Bos taurus

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High impact information on CDK2


Biological context of CDK2

  • Of the regulatory molecules, cyclin D1, CDK2 and CDK4 were expressed in both CAR and ICAR cells derived from both nonpregnant, and AI cows on days 30 and 60 of gestation [5].
  • The cyclin dependent kinase 2 inhibitor, roscovitine, was used to maximize cell cycle synchrony and to produce cells that responded more reliably to nuclear reprogramming [6].

Anatomical context of CDK2


Associations of CDK2 with chemical compounds


Other interactions of CDK2


  1. The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by platelet-derived growth factor and insulin-like growth factor-I. Possible involvement of cyclin-dependent kinase 2. Koyama, H., Nishizawa, Y., Hosoi, M., Fukumoto, S., Kogawa, K., Shioi, A., Morii, H. Circ. Res. (1996) [Pubmed]
  2. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., Kambadur, R. J. Biol. Chem. (2000) [Pubmed]
  3. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor I-mediated suppression of apoptosis in granulosa cells. Hu, C.L., Cowan, R.G., Harman, R.M., Quirk, S.M. Mol. Endocrinol. (2004) [Pubmed]
  4. Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase. Hsu, C.Y., Mechali, F., Bonne-Andrea, C. J. Virol. (2007) [Pubmed]
  5. Proliferative potential of endometrial stromal cells, and endometrial and placental expression of cyclin in the bovine. Yamauchi, N., Takezawa, T., Kizaki, K., Herath, C.B., Hashizume, K. J. Reprod. Dev. (2003) [Pubmed]
  6. Enhanced survivability of cloned calves derived from roscovitine-treated adult somatic cells. Gibbons, J., Arat, S., Rzucidlo, J., Miyoshi, K., Waltenburg, R., Respess, D., Venable, A., Stice, S. Biol. Reprod. (2002) [Pubmed]
  7. Increased phosphorylation of a distinct subcellular pool of protein phosphatase, PP1gamma2, during epididymal sperm maturation. Huang, Z., Vijayaraghavan, S. Biol. Reprod. (2004) [Pubmed]
  8. Kinetics of oocyte maturation and subsequent development of IVF, parthenogenetic, and NT bovine embryos after meiotic inhibition with roscovitine. Lagutina, I., Ponderato, N., Lazzari, G., Galli, C. Cloning Stem Cells (2002) [Pubmed]
  9. The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle. Quirk, S.M., Cowan, R.G., Harman, R.M. J. Endocrinol. (2006) [Pubmed]
  10. Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids. Nixon, C., Chambers, G., Ellsmore, V., Campo, M.S., Burr, P., Argyle, D.J., Reid, S.W., Nasir, L. Cancer Lett. (2005) [Pubmed]
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