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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HAPLN1  -  hyaluronan and proteoglycan link protein 1

Bos taurus

Synonyms: CRTL1, LP
 
 
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Disease relevance of CRTL1

  • The size range of translatable rat chondrosarcoma LP mRNA is 4.0-5.5 kilobase pairs and bovine LP mRNA is 3.0-4.5 kilobase pairs, both much larger than required to encode the link protein molecule [1].
  • We have cloned and ligated a full-length bovine link protein (LP) in the pMAL-c2 vector and overexpressed it in fusion with maltose-binding protein (MBP) in Escherichia coli [2].
 

High impact information on CRTL1

  • Since this enzyme has a specificity for hyaluronic acid, the observations indicate that the lattice contains a backbone of hyaluronic acid (which appeared as banded or filamentous staining) to which is attached LP and PG, the latter collapsing when the tissue is fixed, reacted with antibodies, and prepared for electron microscopy [3].
  • (e) This study demonstrates striking regional variations of ultrastructural organization of PG and LP in articular cartilage.. [3].
  • PG and LP detected by antibody in the interterritorial zones are essentially fully extractible with 4 M guanidine hydrochloride [3].
  • The cyanogen bromide (CNBr) fragments of the two link proteins (LP) were examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis [4].
  • Ethanol administration to rats fed LP or HP diets did not alter the uptake of these proteins as compared with their respective controls [5].
 

Biological context of CRTL1

  • The effect of feeding ethanol daily for 40 days has been studied on intestinal absorption of bovine serum albumin (BSA) and gamma-globulin (IgG) in rats fed a low (8%) protein (LP) or a high (30%) protein (HP) diet [5].
 

Anatomical context of CRTL1

  • Differences in bond strengths between the four systems on enamel and dentine were all statistically significant, excepted for XE vs LP (shear bond at dentine) [6].
 

Associations of CRTL1 with chemical compounds

  • The adhesives tested were Clearfil SE bond (SE), Adper Prompt L Pop (LP), Xeno III (XE), and Prime and Bond NT (PB) [6].
 

Analytical, diagnostic and therapeutic context of CRTL1

  • Monospecific antibodies to bovine cartilage proteoglycan monomer (PG) and link protein (LP) have been used with immunoperoxidase electron microscopy to study the distribution and organization of these molecules in bovine articular cartilage [3].

References

  1. Biosynthesis and cell-free translation of Swarm rat chondrosarcoma and bovine cartilage link proteins. Hering, T.M., Sandell, L.J. J. Biol. Chem. (1988) [Pubmed]
  2. A structural requirement of zinc for the folding of recombinant link protein. Varelas, J.B., Roy, C., Hering, T.M. Arch. Biochem. Biophys. (1997) [Pubmed]
  3. An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage. Poole, A.R., Pidoux, I., Reiner, A., Rosenberg, L. J. Cell Biol. (1982) [Pubmed]
  4. Identity of the protein cores of the two link proteins from bovine nasal cartilage proteoglycan complex. Localization of their sugar moieties. Le Glédic, S., Périn, J.P., Bonnet, F., Jollès, P. J. Biol. Chem. (1983) [Pubmed]
  5. Effect of chronic ethanol administration and dietary protein regimens on intestinal absorption of macromolecules in rats. Kaur, J., Nagpaul, J.P., Singh, K., Mahmood, A. Ann. Nutr. Metab. (1995) [Pubmed]
  6. Sealing ability and bond strength of four contemporary adhesives to enamel and to dentine. Atash, R., Vanden Abbeele, A. European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry. (2005) [Pubmed]
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