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Gene Review

PRDX1  -  peroxiredoxin 1

Bos taurus

 
 
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High impact information on PRDX1

  • 1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, can protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [1].
  • PRDX1 and PRDX5 transcripts were detected throughout development [2].
  • No significant difference in the pattern of PRDX expression was observed under 20% O2 [2].
  • Finally, the potential modulation by oxidative stress of PRDX expression around the major embryonic genome activation was evaluated by culturing embryos under 20% O2 instead of 5% [2].
  • We have previously characterized a peroxiredoxin from bovine ciliary body and deduced its amino acid sequence from analysis of cDNA clones encoding the protein [3].
 

Anatomical context of PRDX1

  • In this study, RT-PCR was used to examine the expression of the six PRDX isoforms (PRDX1 to PRDX6) in bovine oocytes and embryos [2].
 

Analytical, diagnostic and therapeutic context of PRDX1

References

  1. Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Manevich, Y., Feinstein, S.I., Fisher, A.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Expression of peroxiredoxins in bovine oocytes and embryos produced in vitro. Leyens, G., Knoops, B., Donnay, I. Mol. Reprod. Dev. (2004) [Pubmed]
  3. Peroxiredoxin in bovine ocular tissues: immunohistochemical localization and in situ hybridization. Singh, A.K., Shichi, H. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2001) [Pubmed]
 
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