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Gene Review

Prdx1  -  peroxiredoxin 1

Mus musculus

Synonyms: MSP23, Macrophage 23 kDa stress protein, Msp23, NkefA, OSF-3, ...
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Disease relevance of Prdx1


High impact information on Prdx1

  • Pag, also known as macrophage 23-kD stress protein (MSP23), is a member of a novel family of proteins with antioxidant activity implicated in the cellular response to oxidative stress and in control of cell proliferation and differentiation [6].
  • Administration of the cyclooxygenase 2 inhibitor NS-398 to mice with carrageenan-induced pleurisy caused persistence of neutrophil recruitment and, in macrophages, attenuated the 15d-PGJ(2) accumulation and PrxI expression [7].
  • Administration of 15d-PGJ(2) into the pleural space of NS-398-treated wild-type mice largely counteracted both the decrease in PrxI and persistence of neutrophil recruitment [7].
  • Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice [8].
  • With the use both of HeLa cells expressing wild-type or dominant negative forms of the cytosolic peroxidase peroxiredoxin II and of mouse embryonic fibroblasts deficient in this protein, we evaluated the roles of H(2)O(2) in the activation of MAPKs by TNF-alpha [9].

Chemical compound and disease context of Prdx1

  • In particular, several proteins that are known to be associated with hypoxia were elevated, for example, glycolytic enzymes, glucose-regulated protein 78 kD, prolyl-4-hydroxylase, peroxiredoxin 1, and arginase [10].

Biological context of Prdx1


Anatomical context of Prdx1


Associations of Prdx1 with chemical compounds


Regulatory relationships of Prdx1

  • In the absence of KatG, antioxidant protection is provided by enhanced expression of the peroxiredoxin AhpC, which is itself reduced by AhpD, a protein with low alkylhydroperoxidase activity of its own [19].
  • Moreover, the activation of nuclear factor kappaB (NFkappaB) induced by extracellularly added H2O2 or tumor necrosis factor-alpha was blocked by overproduction of Prx II [20].

Other interactions of Prdx1

  • The transcription factor Nrf2, however, was not involved in the regulation of Prx I promoter activity [12].
  • Most notably, c-Myc-mediated transformation is inhibited, implying a tumor suppressor role for Prdx1 [21].
  • Proteomic analysis of the Prdx1 knock-down cells revealed that the level of NF-kappaB inhibitor epsilon (IkappaBepsilon) was dramatically reduced [11].
  • We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes [2].
  • Pag, a member of the peroxiredoxin family, has been reported previously to bind to and inhibit the cytostatic properties of the c-Abl oncoprotein [22].

Analytical, diagnostic and therapeutic context of Prdx1


  1. Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells. Hoshino, I., Matsubara, H., Hanari, N., Mori, M., Nishimori, T., Yoneyama, Y., Akutsu, Y., Sakata, H., Matsushita, K., Seki, N., Ochiai, T. Clin. Cancer Res. (2005) [Pubmed]
  2. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Neumann, C.A., Krause, D.S., Carman, C.V., Das, S., Dubey, D.P., Abraham, J.L., Bronson, R.T., Fujiwara, Y., Orkin, S.H., Van Etten, R.A. Nature (2003) [Pubmed]
  3. Cloning and characterization of OSF-3, a new member of the MER5 family, expressed in mouse osteoblastic cells. Kawai, S., Takeshita, S., Okazaki, M., Kikuno, R., Kudo, A., Amann, E. J. Biochem. (1994) [Pubmed]
  4. Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Kim, B.J., Hood, B.L., Aragon, R.A., Hardwick, J.P., Conrads, T.P., Veenstra, T.D., Song, B.J. Proteomics (2006) [Pubmed]
  5. Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. Nonn, L., Berggren, M., Powis, G. Mol. Cancer Res. (2003) [Pubmed]
  6. The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Wen, S.T., Van Etten, R.A. Genes Dev. (1997) [Pubmed]
  7. Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., Yamamoto, M. Mol. Cell. Biol. (2004) [Pubmed]
  8. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Lee, T.H., Kim, S.U., Yu, S.L., Kim, S.H., Park, d.o. .S., Moon, H.B., Dho, S.H., Kwon, K.S., Kwon, H.J., Han, Y.H., Jeong, S., Kang, S.W., Shin, H.S., Lee, K.K., Rhee, S.G., Yu, D.Y. Blood (2003) [Pubmed]
  9. Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha. Kang, S.W., Chang, T.S., Lee, T.H., Kim, E.S., Yu, D.Y., Rhee, S.G. J. Biol. Chem. (2004) [Pubmed]
  10. Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Fajardo, I., Svensson, L., Bucht, A., Pejler, G. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  11. Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Shan, S.W., Tang, M.K., Cai, D.Q., Chui, Y.L., Chow, P.H., Grotewold, L., Lee, K.K. Dev. Dyn. (2005) [Pubmed]
  12. Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway. Hess, A., Wijayanti, N., Neuschäfer-Rube, A.P., Katz, N., Kietzmann, T., Immenschuh, S. J. Biol. Chem. (2003) [Pubmed]
  13. Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. Li, B., Ishii, T., Tan, C.P., Soh, J.W., Goff, S.P. J. Biol. Chem. (2002) [Pubmed]
  14. Histological recovery of the hepatocytes is based on the redox system upregulation in the animal models of mutant superoxide dismutase (SOD)1-linked amyotrophic lateral sclerosis. Kato, M., Kato, S., Abe, Y., Nishino, T., Ohama, E., Aoki, M., Itoyama, Y. Histol. Histopathol. (2006) [Pubmed]
  15. Induction of 1-cys peroxiredoxin expression by oxidative stress in lung epithelial cells. Kim, H.S., Manevich, Y., Feinstein, S.I., Pak, J.H., Ho, Y.S., Fisher, A.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  16. Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence. Woo, H.A., Kang, S.W., Kim, H.K., Yang, K.S., Chae, H.Z., Rhee, S.G. J. Biol. Chem. (2003) [Pubmed]
  17. Induction of murine intestinal and hepatic peroxiredoxin MSP23 by dietary butylated hydroxyanisole. Ishii, T., Itoh, K., Akasaka, J., Yanagawa, T., Takahashi, S., Yoshida, H., Bannai, S., Yamamoto, M. Carcinogenesis (2000) [Pubmed]
  18. Contrasting antioxidant and cytotoxic effects of peroxiredoxin I and II in PC12 and NIH3T3 cells. Simzar, S., Ellyin, R., Shau, H., Sarafian, T.A. Neurochem. Res. (2000) [Pubmed]
  19. Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Koshkin, A., Zhou, X.T., Kraus, C.N., Brenner, J.M., Bandyopadhyay, P., Kuntz, I.D., Barry, C.E., Ortiz de Montellano, P.R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  20. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. Kang, S.W., Chae, H.Z., Seo, M.S., Kim, K., Baines, I.C., Rhee, S.G. J. Biol. Chem. (1998) [Pubmed]
  21. Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Egler, R.A., Fernandes, E., Rothermund, K., Sereika, S., de Souza-Pinto, N., Jaruga, P., Dizdaroglu, M., Prochownik, E.V. Oncogene (2005) [Pubmed]
  22. Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression. Mu, Z.M., Yin, X.Y., Prochownik, E.V. J. Biol. Chem. (2002) [Pubmed]
  23. Cloning and expression of mouse peroxiredoxin I in IEC-6 Cells. Zhang, B., Su, Y.P., Wang, T., Wang, F.C., Ai, G.P., Xu, H., Wang, J.P., Huang, Y.S., Jiang, J.X. World J. Gastroenterol. (2004) [Pubmed]
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