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Gene Review

Prdx1  -  peroxiredoxin 1

Rattus norvegicus

Synonyms: HBP23, Heme-binding 23 kDa protein, Peroxiredoxin-1, Tdpx2, Thioredoxin peroxidase 2, ...
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Disease relevance of Prdx1

  • Treatment of primary rat hepatocyte or hepatoma cell cultures with the heavy metals CdCl2 (10 microM) and CoCl2 (300 microM) induced in parallel HBP23 and HO-1 mRNA levels, in the case of CdCl2 to even higher levels than heme [1].

Psychiatry related information on Prdx1

  • HBP23 was constitutively expressed in KC and up-regulated on the protein and messenger RNA (mRNA) level by LPS with a time response distinct from that of TNFalpha, but in coordination with that of heme oxygenase-1 (HO-1), which is the inducible isoform of the rate-limiting enzyme of heme degradation [2].

High impact information on Prdx1


Biological context of Prdx1


Anatomical context of Prdx1


Associations of Prdx1 with chemical compounds


Regulatory relationships of Prdx1

  • HBP23 mRNA induction by LPS was down-regulated by interleukin 10 and transforming growth factor beta1 with a NO-independent mechanism [2].

Other interactions of Prdx1

  • While HO-1 mRNA was induced up to 48 hr, Prx I exhibited a maximum level of mRNA after 12 hr of treatment with CCl4 [4].
  • HBP23/Prx I induction by OA occurred on the transcriptional level as determined by studies with actinomycin D and nuclear run-off assays [6].
  • Immunodepletion of the 28-kDa peroxiredoxin profoundly decreased the antioxidant activity of the olfactory tissue extract [9].
  • However, by using matrix-assisted laser dissociation/ionization time-of-flight mass spectrometry (MALDI-TOF MS), we identified several other proteins which are susceptible to S-nitrosylation in liver microsomes, including retinol dehydrogenase type I (RODH I), aldolase B, cytochrome P4502C11, and peroxiredoxin 1 [10].

Analytical, diagnostic and therapeutic context of Prdx1


  1. Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Immenschuh, S., Iwahara, S., Satoh, H., Nell, C., Katz, N., Muller-Eberhard, U. Biochemistry (1995) [Pubmed]
  2. Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells. Immenschuh, S., Stritzke, J., Iwahara, S., Ramadori, G. Hepatology (1999) [Pubmed]
  3. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Hirotsu, S., Abe, Y., Okada, K., Nagahara, N., Hori, H., Nishino, T., Hakoshima, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Complementary regulation of heme oxygenase-1 and peroxiredoxin I gene expression by oxidative stress in the liver. Immenschuh, S., Fahimi, H.D., Baumgart-Vogt, E. Cell. Mol. Biol. (Noisy-le-grand) (2005) [Pubmed]
  5. Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Iwahara, S., Satoh, H., Song, D.X., Webb, J., Burlingame, A.L., Nagae, Y., Muller-Eberhard, U. Biochemistry (1995) [Pubmed]
  6. Induction of heme-binding protein 23/peroxiredoxin I gene expression by okadaic acid in cultured rat hepatocytes. Immenschuh, S., Iwahara, S., Schwennen, B. DNA Cell Biol. (2002) [Pubmed]
  7. A proteomic investigation of drug-induced steatosis in rat liver. Meneses-Lorente, G., Guest, P.C., Lawrence, J., Muniappa, N., Knowles, M.R., Skynner, H.A., Salim, K., Cristea, I., Mortishire-Smith, R., Gaskell, S.J., Watt, A. Chem. Res. Toxicol. (2004) [Pubmed]
  8. Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver. Immenschuh, S., Baumgart-Vogt, E., Tan, M., Iwahara, S., Ramadori, G., Fahimi, H.D. J. Histochem. Cytochem. (2003) [Pubmed]
  9. Localization of 28-kDa peroxiredoxin in rat epithelial tissues and its antioxidant properties. Novoselov, S.V., Peshenko, I.V., Popov, V.I., Novoselov, V.I., Bystrova, M.F., Evdokimov, V.J., Kamzalov, S.S., Merkulova, M.I., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E. Cell Tissue Res. (1999) [Pubmed]
  10. Microsomal glutathione transferase 1 is not S-nitrosylated in rat liver microsomes or in endotoxin challenged rats. Shi, Q., Lou, Y.J. Pharmacol. Res. (2005) [Pubmed]
  11. Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii. Kawazu, S., Nozaki, T., Tsuboi, T., Nakano, Y., Komaki-Yasuda, K., Ikenoue, N., Torii, M., Kano, S. Int. J. Parasitol. (2003) [Pubmed]
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