Gene Review:
DYNLT1 - dynein, light chain, Tctex-type 1
Bos taurus
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High impact information on TCTEL1
- In this study, we find that Tctex-1, a light chain of cytoplasmic dynein, localizes predominantly to the Golgi apparatus in interphase fibroblasts [1].
- Tctex-1 colocalization with Golgi compartment markers, its distribution upon treatment with various pharmacological agents, and the cofractionation of Tctex-1-associated membranes with Golgi membranes are all consistent with a Golgi localization [1].
Analytical, diagnostic and therapeutic context of TCTEL1
- Using sequential immunoprecipitations, we demonstrate that there is a subset of Tctex-1 not associated with the intermediate chain at steady state; the converse also appears to be true [1].
- The distribution of Tctex-1 in interphase cells only partially overlaps with the dynein intermediate chain and p150(Glued) upon immunofluorescence, but most of Tctex-1 is redistributed onto mitotic spindles along with other dynein/dynactin subunits [1].
References
- Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity. Tai, A.W., Chuang, J.Z., Sung, C.H. J. Biol. Chem. (1998) [Pubmed]
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