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Gene Review

Dlc90F  -  Dynein light chain 90F

Drosophila melanogaster

Synonyms: CG12363, Dmel\CG12363, Dynein light chain Tctex-type, TCTEX-1 protein homolog, TcTex-1, ...
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Disease relevance of Dlc90F

  • Four P-transposon insertions which disrupt the 5' untranslated region of dtctex-1 are viable in homozygous form but cause male sterility due to the production of non-motile sperm [1].

High impact information on Dlc90F

  • Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate [2].
  • We found that roadblock, which encodes a dynein light chain, exhibits reduced cell number in neuroblast clones, reduced dendritic complexity and defective axonal transport [3].
  • These results demonstrate a new function for the cytoplasmic dynein light chain in the regulation of axonogenesis and may provide a point of entry for studies of the role of cellular motors in growth cone guidance [4].
  • The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation [5].
  • Saturation screening of both mouse embryo and mouse testis libraries yielded 14 independent clones, all of which represented two different isoforms of dynein light chain [6].

Biological context of Dlc90F

  • Dlc1, a member of the Tctex-1 dynein light-chain family, preferentially affects the segregation of achiasmate chromosomes [7].
  • Consistent with this model, point mutations that specifically disrupt Egl-Dlc association also disrupt microtubule-dependant trafficking both to and within the oocyte, resulting in a loss of oocyte fate maintenance and polarity [2].
  • Although the two DLC8-binding peptides have entirely different amino acid sequences, both peptides bind to the protein with a remarkable similar conformation by engaging the symmetric DLC8 dimer through antiparallel beta-sheet augmentation via the beta2 strand of the protein [8].
  • Their open reading frames respectively encode 96 amino acids which are most closely homologous to roadblock/LC7, one member of an ancient dynein light chain protein family, conserved in nematode, fruit fly, mouse and rat [9].

Other interactions of Dlc90F

  • A smaller but reproducible change in the CD spectra was observed upon Tctex-1 binding as well [10].


  1. dtctex-1, the Drosophila melanogaster homolog of a putative murine t-complex distorter encoding a dynein light chain, is required for production of functional sperm. Caggese, C., Moschetti, R., Ragone, G., Barsanti, P., Caizzi, R. Mol. Genet. Genomics (2001) [Pubmed]
  2. Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Navarro, C., Puthalakath, H., Adams, J.M., Strasser, A., Lehmann, R. Nat. Cell Biol. (2004) [Pubmed]
  3. A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis. Reuter, J.E., Nardine, T.M., Penton, A., Billuart, P., Scott, E.K., Usui, T., Uemura, T., Luo, L. Development (2003) [Pubmed]
  4. Mutations in the 8 kDa dynein light chain gene disrupt sensory axon projections in the Drosophila imaginal CNS. Phillis, R., Statton, D., Caruccio, P., Murphey, R.K. Development (1996) [Pubmed]
  5. The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. Li, M.G., Serr, M., Newman, E.A., Hays, T.S. Mol. Biol. Cell (2004) [Pubmed]
  6. Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila. Herzig, R.P., Andersson, U., Scarpulla, R.C. J. Cell. Sci. (2000) [Pubmed]
  7. Dynein promotes achiasmate segregation in Schizosaccharomyces pombe. Davis, L., Smith, G.R. Genetics (2005) [Pubmed]
  8. Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. Fan, J., Zhang, Q., Tochio, H., Li, M., Zhang, M. J. Mol. Biol. (2001) [Pubmed]
  9. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. Jiang, J., Yu, L., Huang, X., Chen, X., Li, D., Zhang, Y., Tang, L., Zhao, S. Gene (2001) [Pubmed]
  10. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Makokha, M., Hare, M., Li, M., Hays, T., Barbar, E. Biochemistry (2002) [Pubmed]
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