The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DYNLT1  -  dynein, light chain, Tctex-type 1

Homo sapiens

Synonyms: CW-1, Dynein light chain Tctex-type 1, Protein CW-1, T-complex testis-specific protein 1 homolog, TCTEL1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DYNLT1

  • Association with Tctex-1 and, hence, with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular transport machinery to retrogradely ascend along the axon to the neuronal cell body [1].
  • To investigate intracellular transport, the recombinant viral capsids were microinjected into living cells and incubated at 37 degrees C. After 1 h VP26+ capsids were observed to co-localize with RP3, Tctex1, and microtubules [2].
  • Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1 [3].
  • Rheumatoid-like PsPA patients have increased DR4, B40 frequencies; those with spondylitis, B27, CW1 [4].

Psychiatry related information on DYNLT1


High impact information on DYNLT1

  • Taken together, these data demonstrate a discrete function for the cytoplasmic domain of BMPR-II and justify further investigation of whether the interaction with and phosphorylation of Tctex-1 contributes to the pathogenesis of PPH [6].
  • To overcome this problem, we generated two lines of homozygous diploid clonal zebrafish lines (i.e., CB1 and CW1), which allowed us to carry out transplantation of any tissue, including tumors, from one fish to another within a line without rejection of the graft [7].
  • We performed yeast two-hybrid screening of a human placental cDNA library and isolated a new endoglin-binding partner, a novel 221-amino acid member of the Tctex1/2 family of cytoplasmic dynein light chains named Tctex2beta, as the founder of a new Tctex1/2 subfamily [8].
  • The complex was detected in HeLa cells treated with H(2)O(2) or TNF-alpha but not in untreated cells, suggesting that LC8 cytoplasmic dynein light chain is a possible substrate of TRP14 [9].
  • We confirmed the interaction biochemically and by co-immunoprecipitation, and we mapped the Tctex-1 binding site to a SKCSR motif within the juxtamembrane region of CD155 [1].

Biological context of DYNLT1

  • Folding is coupled to dimerization of Tctex-1 dynein light chain [10].
  • Additionally, immunohistochemical staining showed co-expression of HSPB9 and TCTEL1 in similar stages of spermatogenesis and in tumour cells [3].
  • The cDNA, designated TCTEL1, contained an open reading frame of 339 nucleotides encoding 113 amino acids [11].
  • As Tctex-1 is a candidate for involvement in the transmission ratio distortion (meiotic drive) of mouse t-haplotypes, these results suggest that cytoplasmic dynein dysfunction may play an important role in non-mendelian chromosome segregation [12].
  • In contrast, two sequence motifs, one believed to confer binding to the cytoplasmic dynein light chain LC8, and a lysine-rich sequence probably contributing to N protein binding, were conserved throughout the genus [13].

Anatomical context of DYNLT1


Associations of DYNLT1 with chemical compounds


Physical interactions of DYNLT1

  • A yeast two-hybrid screen for tastin-interacting proteins identified Tctex-1, one of the light chains of cytoplasmic dynein, as a tastin-binding protein [14].
  • PTH/PTH-related protein receptor interacts directly with Tctex-1 through its COOH terminus [17].

Regulatory relationships of DYNLT1

  • A GFP-fused mutant PTHR impaired in binding to Tctex-1 expressed in MDCK cells showed a decreased rate of internalization in response to PTH compared to that of the wild type [17].

Other interactions of DYNLT1


Analytical, diagnostic and therapeutic context of DYNLT1

  • Immunoprecipitation and Western-blot analysis confirmed binding of HA-tagged tastin and FLAG (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys epitope)-tagged Tctex-1 in human cells [14].
  • Quantitative densitometry indicates that Tctex-1 is a stoichiometric component of the dynein complex [12].
  • The absence of HLA-A24 and CW1 was also significant in group I. The frequencies of HLA A2, B8, B13, CW3, DR13 were significantly higher in group II compared to the control group [22].


  1. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. Mueller, S., Cao, X., Welker, R., Wimmer, E. J. Biol. Chem. (2002) [Pubmed]
  2. Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. Douglas, M.W., Diefenbach, R.J., Homa, F.L., Miranda-Saksena, M., Rixon, F.J., Vittone, V., Byth, K., Cunningham, A.L. J. Biol. Chem. (2004) [Pubmed]
  3. Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. de Wit, N.J., Verschuure, P., Kappé, G., King, S.M., de Jong, W.W., van Muijen, G.N., Boelens, W.C. Eur. J. Cell Biol. (2004) [Pubmed]
  4. Human lymphocyte antigens characterizing psoriatic arthritis and its subtypes. Gerber, L.H., Murray, C.L., Perlman, S.G., Barth, W.F., Decker, J.L., Nigra, T.A., Mann, D.L. J. Rheumatol. (1982) [Pubmed]
  5. cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Sironen, R.K., Karjalainen, H.M., Elo, M.A., Kaarniranta, K., Törrönen, K., Takigawa, M., Helminen, H.J., Lammi, M.J. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Machado, R.D., Rudarakanchana, N., Atkinson, C., Flanagan, J.A., Harrison, R., Morrell, N.W., Trembath, R.C. Hum. Mol. Genet. (2003) [Pubmed]
  7. Transplantable tumor lines generated in clonal zebrafish. Mizgireuv, I.V., Revskoy, S.Y. Cancer Res. (2006) [Pubmed]
  8. Identification of Tctex2beta, a Novel Dynein Light Chain Family Member That Interacts with Different Transforming Growth Factor-beta Receptors. Meng, Q., Lux, A., Holloschi, A., Li, J., Hughes, J.M., Foerg, T., McCarthy, J.E., Heagerty, A.M., Kioschis, P., Hafner, M., Garland, J.M. J. Biol. Chem. (2006) [Pubmed]
  9. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. Jeong, W., Chang, T.S., Boja, E.S., Fales, H.M., Rhee, S.G. J. Biol. Chem. (2004) [Pubmed]
  10. Folding is coupled to dimerization of Tctex-1 dynein light chain. Talbott, M., Hare, M., Nyarko, A., Hays, T.S., Barbar, E. Biochemistry (2006) [Pubmed]
  11. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. Watanabe, T.K., Fujiwara, T., Shimizu, F., Okuno, S., Suzuki, M., Takahashi, E., Nakamura, Y., Hirai, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  12. The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. King, S.M., Dillman, J.F., Benashski, S.E., Lye, R.J., Patel-King, R.S., Pfister, K.K. J. Biol. Chem. (1996) [Pubmed]
  13. Lyssavirus P gene characterisation provides insights into the phylogeny of the genus and identifies structural similarities and diversity within the encoded phosphoprotein. Nadin-Davis, S.A., Abdel-Malik, M., Armstrong, J., Wandeler, A.I. Virology (2002) [Pubmed]
  14. Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. Nadano, D., Nakayama, J., Matsuzawa, S., Sato, T.A., Matsuda, T., Fukuda, M.N. Biochem. J. (2002) [Pubmed]
  15. Dynein light chain Tctex-1 identifies neural progenitors in adult brain. Dedesma, C., Chuang, J.Z., Alfinito, P.D., Sung, C.H. J. Comp. Neurol. (2006) [Pubmed]
  16. Identification of a dynein molecular motor component in Torpedo electroplax; binding and phosphorylation of Tctex-1 by Fyn. Mou, T., Kraas, J.R., Fung, E.T., Swope, S.L. FEBS Lett. (1998) [Pubmed]
  17. PTH/PTH-related protein receptor interacts directly with Tctex-1 through its COOH terminus. Sugai, M., Saito, M., Sukegawa, I., Katsushima, Y., Kinouchi, Y., Nakahata, N., Shimosegawa, T., Yanagisawa, T., Sukegawa, J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  18. Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. Ohka, S., Matsuda, N., Tohyama, K., Oda, T., Morikawa, M., Kuge, S., Nomoto, A. J. Virol. (2004) [Pubmed]
  19. Heteronuclear NMR identifies a nascent helix in intrinsically disordered Dynein intermediate chain: implications for folding and dimerization. Benison, G., Nyarko, A., Barbar, E. J. Mol. Biol. (2006) [Pubmed]
  20. Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. Shen, X.Y., Zacal, N., Singh, G., Rainbow, A.J. Photochem. Photobiol. (2005) [Pubmed]
  21. Regulatory dissociation of tctex-1 light chain from Dynein complex is essential for the apical delivery of rhodopsin. Yeh, T.Y., Peretti, D., Chuang, J.Z., Rodriguez-Boulan, E., Sung, C.H. Traffic (2006) [Pubmed]
  22. The role of HLA antigens in chronic hepatitis B virus infection. Karan, M.A., Tascioglu, N.E., Ozturk, A.O., Palanduz, S., Carin, M. JPMA. The Journal of the Pakistan Medical Association. (2002) [Pubmed]
WikiGenes - Universities