Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Slco1a6 - solute carrier organic anion transporter...

Mus musculus

Synonyms: 4930422F19Rik, AI790453, Kidney-specific organic anion-transporting polypeptide 5, OATP-5, Oatp-5, ...

Choudhuri, S. et al., Li, N. et al., Enokizono, J. et al., Obrador, E. et al.

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Disease relevance of Slco1a6

The basal-to-apical transport of TGZS was enhanced in organic anion transporting polypeptide 1B1-expressing Madin-Darby canine kidney II cells by infection of recombinant adenovirus harboring human BCRP and mouse Bcrp cDNA [1].

High impact information on Slco1a6

Organic anion transporting polypeptide 1-independent sinusoidal GSH efflux from hepatocytes increased in B16MF1/Tet-GGT- or B16MF10-bearing mice ( approximately 2-fold, P <.01) as compared with non-tumor-bearing mice [2].
Organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is expressed almost exclusively in liver, where it mediates uptake of a variety of compounds, including bile acids, as well as other endo- and xenobiotics, across hepatic sinusoidal membranes in a Na+-independent manner [3].
Deduced amino acid sequence of mouse Oatp-5 protein contains 670 amino acids and has 10 putative transmembrane domains, multiple potential glycosylation and phosphorylation sites [4].
The 3'-untranslated region (3'-UTR) of Oatp-5 cDNA contains an early polyadenylation signal, indicating the possibility that mRNAs with different 3'-UTR lengths may coexist [4].
Analysis of the 5'-untranslated region (5'-UTR) of Oatp-5 cDNA through capsite cloning reveals two possible transcription start sites that are 4-bp apart [4].

Biological context of Slco1a6

The full-length coding sequence of mouse organic anion-transporting polypeptide (designated mouse Oatp-5) has been cloned from mouse kidney cDNA library [4].

References

Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect. Enokizono, J., Kusuhara, H., Sugiyama, Y. Drug Metab. Dispos. (2007) [Pubmed]
gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver. Obrador, E., Carretero, J., Ortega, A., Medina, I., Rodilla, V., Pellicer, J.A., Estrela, J.M. Hepatology (2002) [Pubmed]
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. Li, N., Klaassen, C.D. Toxicol. Sci. (2005) [Pubmed]
Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. Choudhuri, S., Ogura, K., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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