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Gene Review

Slco1b2  -  solute carrier organic anion transporter...

Mus musculus

Synonyms: 7330442B20Rik, LST-1, Liver-specific organic anion transporter 1, OATP-C, OATP2, ...
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Disease relevance of Slco1b2

  • Multiple copies of the Oatp4 HNF1alpha response element, inserted upstream of a minimal promoter, were sufficient to mediate reporter activity and responded to the coexpression of HNF1alpha in mouse hepatoma cells [1].
  • LST-1 and its polymorphism may be used as an additional marker of the TNF region, where genes responsible for autoimmune diseases are suspected to be localized [2].
  • Taken together, these data demonstrate a pivotal role for PXR in the regulation of drug-induced hepatomegaly and in the metabolism (CYP3A), transport (Oatp2), biosynthesis (Cyp7a1), and excretion of xenobiotics and bile acids in vivo [3].
  • PVU II polymorphism of LST-1 (leucocyte specific transcript-1) in type I diabetes mellitus, Graves' disease and healthy controls [4].

Psychiatry related information on Slco1b2

  • For the time-response study, LPS (5 mg/kg i.p.) produced a rapid decrease in Oatp4 mRNA levels in TLR4-normal C3H/OuJ mice [5].

High impact information on Slco1b2


Biological context of Slco1b2

  • The deduced amino acid sequence of the mouse lst-1 shares 64 and 77% identities with the reported human and rat lsts, respectively [9].
  • The mouse lst-1 gene spans approximately 60 kbp in length and consists of 16 exons, including two noncoding exons [9].
  • HNF1alpha bound to the Oatp4 HNF1 response element as a homodimer [1].
  • Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter [1].
  • The full-length rat lst-1 (designated rlst-1a) encodes a protein containing 687 amino acids and has 12-putative transmembrane domains, multiple potential N-glycosylation and phosphorylation sites [10].

Anatomical context of Slco1b2

  • In cellular uptake studies using a conditionally immortalized mouse brain capillary endothelial cell line (TM-BBB4), [(3)H]DHEAS uptake by TM-BBB4 cells exhibited a concentration dependence with a K:(m) of 34.4 microM: and was significantly inhibited by the oatp2-specific substrate digoxin [11].
  • Organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is expressed almost exclusively in liver, where it mediates uptake of a variety of compounds, including bile acids, as well as other endo- and xenobiotics, across hepatic sinusoidal membranes in a Na+-independent manner [12].

Associations of Slco1b2 with chemical compounds


Regulatory relationships of Slco1b2

  • Thus, TLR4 is considered an upstream mediator of LPS-induced decrease in mouse Oatp4 mRNA [12].

Analytical, diagnostic and therapeutic context of Slco1b2

  • Northern blot analysis demonstrates that mouse lst-1 mRNA is expressed exclusively in liver [9].
  • In conclusion, DHEAS efflux transport takes place across the BBB, and studies involving in vitro DHEAS uptake and RT-PCR suggest that there is oatp2-mediated DHEAS transport at the BBB [11].
  • RT-PCR and sequence analysis suggest that an oatp2 is expressed in TM-BBB4 cells [11].


  1. Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide. Li, N., Klaassen, C.D. Mol. Pharmacol. (2004) [Pubmed]
  2. Pvu II polymorphism in the primate homologue of the mouse B144 (LST-1). A novel marker gene within the tumor necrosis factor region. de Baey, A., Holzinger, I., Scholz, S., Keller, E., Weiss, E.H., Albert, E. Hum. Immunol. (1995) [Pubmed]
  3. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Staudinger, J., Liu, Y., Madan, A., Habeebu, S., Klaassen, C.D. Drug Metab. Dispos. (2001) [Pubmed]
  4. PVU II polymorphism of LST-1 (leucocyte specific transcript-1) in type I diabetes mellitus, Graves' disease and healthy controls. Rau, H., Usadel, K.H., Ommert, S., Badenhoop, K. Eur. J. Immunogenet. (1995) [Pubmed]
  5. Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). Li, N., Choudhuri, S., Cherrington, N.J., Klaassen, C.D. Drug Metab. Dispos. (2004) [Pubmed]
  6. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Wagner, M., Halilbasic, E., Marschall, H.U., Zollner, G., Fickert, P., Langner, C., Zatloukal, K., Denk, H., Trauner, M. Hepatology (2005) [Pubmed]
  7. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. Kitada, H., Miyata, M., Nakamura, T., Tozawa, A., Honma, W., Shimada, M., Nagata, K., Sinal, C.J., Guo, G.L., Gonzalez, F.J., Yamazoe, Y. J. Biol. Chem. (2003) [Pubmed]
  8. Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression. Chen, C., Cheng, X., Dieter, M.Z., Tanaka, Y., Klaassen, C.D. Mol. Pharmacol. (2007) [Pubmed]
  9. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Ogura, K., Choudhuri, S., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. Choudhuri, S., Ogura, K., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  11. Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. Asaba, H., Hosoya, K., Takanaga, H., Ohtsuki, S., Tamura, E., Takizawa, T., Terasaki, T. J. Neurochem. (2000) [Pubmed]
  12. Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. Li, N., Klaassen, C.D. Toxicol. Sci. (2005) [Pubmed]
  13. Uptake and efflux of the peptidic delta-opioid receptor agonist. Dagenais, C., Ducharme, J., Pollack, G.M. Neurosci. Lett. (2001) [Pubmed]
  14. Regulation of drug transporter gene expression by nuclear receptors. Staudinger, J.L., Madan, A., Carol, K.M., Parkinson, A. Drug Metab. Dispos. (2003) [Pubmed]
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