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Gene Review

IFNL3  -  interferon, lambda 3

Homo sapiens

Synonyms: Cytokine Zcyto22, IFN-lambda-3, IL-28B, IL-28C, IL28B, ...
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Disease relevance of IL28B


High impact information on IL28B


Biological context of IL28B


Other interactions of IL28B

  • The antiviral activity of IL-28A, IL-28B, and IL-29 was determined by a cytopathic effect reduction assay on WISH cells using VSV as a challenge virus [1].

Pharmacogenetic implications of IL28B

  • A single nucleotide polymorphism (SNP) near IL-28B has been shown to predict response to Hepatitis C treatment  .


  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Li, M.C., Wang, H.Y., Wang, H.Y., Li, T., He, S.H. Acta Pharmacol. Sin. (2006) [Pubmed]
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