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Gene Review:

IFNL3 - interferon, lambda 3

Homo sapiens

Synonyms: Cytokine Zcyto22, IFN-lambda-3, IL-28B, IL-28C, IL28B, ...

Li, M.C. et al., Potikyan, G.

Gary Potikyan,

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Disease relevance of IL28B

AIM: To construct the recombinant vectors carrying interleukin (IL)-28A, IL-28B and IL-29 cDNAs and express them in human A549 cells, and analyze their antiviral activity in vesicular stomatitis virus (VSV)-infected human immortalized amnion epithelial cell line (WISH cells) [1].

High impact information on IL28B

Semiquantitative RT-PCR and Western blotting were used to detect the mRNA and protein expression of IL-28A, IL-28B, and IL-29 [1].

Biological context of IL28B

The cDNAs encoding human IL-28A, IL-28B, and IL-29 were amplified by reverse-transcription polymerase chain reaction (RT-PCR) and inserted into pcDNA3.1/V5-His-TOPO vectors [1].

Other interactions of IL28B

The antiviral activity of IL-28A, IL-28B, and IL-29 was determined by a cytopathic effect reduction assay on WISH cells using VSV as a challenge virus [1].

Pharmacogenetic implications of IL28B

A single nucleotide polymorphism (SNP) near IL-28B has been shown to predict response to Hepatitis C treatment .

References

Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Li, M.C., Wang, H.Y., Wang, H.Y., Li, T., He, S.H. Acta Pharmacol. Sin. (2006) [Pubmed]

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LOC100298542	Bos taurus
LOC612543	Canis lupus familiaris
LOC101751261	Gallus gallus
IFNL3	Gallus gallus
Ifnl3	Mus musculus
Ifnl2	Mus musculus
IFNL3	Pan troglodytes
LOC100911249	Rattus norvegicus
Ifnl3	Rattus norvegicus

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