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Gene Review

IFNL2  -  interferon, lambda 2

Homo sapiens

Synonyms: Cytokine Zcyto20, IFN-lambda-2, IL-28A, IL28A, Interferon lambda-2, ...
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Disease relevance of IL28A


High impact information on IL28A

  • Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO) [3].
  • Finally, IL-28A-specific antisense phosphorothioate oligonucleotides suppressed liver pathology in Con A-treated wild-type mice, as compared with the case of control oligonucleotides [4].
  • METHODS: We cloned the murine IL-28A gene by reverse-transcription polymerase chain reaction, assessed the effects of recombinant IL-28A, and generated IL-28A-transgenic mice [4].
  • IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet [4].
  • To prepare specific monoclonal antibody against human IL-28A, BALB/c mice were immunized with IL-28A, and hybridoma cell lines were obtained by fusing mouse spleen cells with myeloma NS-1 cells [2].

Biological context of IL28A


Anatomical context of IL28A


Other interactions of IL28A

  • In this study, we investigated the effects of the IFN-lambdas IL-28A and IL-29 on human neuroendocrine BON1 tumor cells [8].
  • The antiviral activity of IL-28A, IL-28B, and IL-29 was determined by a cytopathic effect reduction assay on WISH cells using VSV as a challenge virus [5].

Analytical, diagnostic and therapeutic context of IL28A


  1. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Zhu, H., Butera, M., Nelson, D.R., Liu, C. Virol. J. (2005) [Pubmed]
  2. Production, characterization, and applications of two novel monoclonal antibodies against human interleukin-28A. Li, M., Chen, Y., Huang, T., Liu, Y., He, S. Tissue Antigens (2006) [Pubmed]
  3. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Kotenko, S.V., Gallagher, G., Baurin, V.V., Lewis-Antes, A., Shen, M., Shah, N.K., Langer, J.A., Sheikh, F., Dickensheets, H., Donnelly, R.P. Nat. Immunol. (2003) [Pubmed]
  4. IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet. Siebler, J., Wirtz, S., Weigmann, B., Atreya, I., Schmitt, E., Kreft, A., Galle, P.R., Neurath, M.F. Gastroenterology (2007) [Pubmed]
  5. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Li, M.C., Wang, H.Y., Wang, H.Y., Li, T., He, S.H. Acta Pharmacol. Sin. (2006) [Pubmed]
  6. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. Brand, S., Beigel, F., Olszak, T., Zitzmann, K., Eichhorst, S.T., Otte, J.M., Diebold, J., Diepolder, H., Adler, B., Auernhammer, C.J., Göke, B., Dambacher, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  7. Biological activity of interleukins-28 and -29: comparison with type I interferons. Meager, A., Visvalingam, K., Dilger, P., Bryan, D., Wadhwa, M. Cytokine (2005) [Pubmed]
  8. Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells. Zitzmann, K., Brand, S., Baehs, S., Göke, B., Meinecke, J., Spöttl, G., Meyer, H., Auernhammer, C.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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