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Gene Review:

AQP11 - aquaporin 11

Homo sapiens

Synonyms: AQP-11, AQPX1, Aquaporin-11, PSEC0027

Morishita, Y. et al., Gorelick, D.A. et al.

Gorelick, Praetorius, Tsunenari, Nielsen, Agre,

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Disease relevance of AQP11

AQP11-null mice are a novel model for polycystic kidney diseases and will provide a new mechanism for cystogenesis [1].

High impact information on AQP11

Primary cultured cells of the proximal tubule revealed an endosomal acidification defect in AQP11-null mice [1].
When AQP11 was transfected in CHO-K1 cells, it was localized in intracellular organelles [1].
AQP11 has a unique distribution in brain, appearing in Purkinje cell dendrites, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons [2].
Unlike other aquaporins, Xenopus oocytes expressing AQP11 in the plasma membrane failed to transport water, glycerol, urea, or ions [2].
Immunofluorescent staining of Purkinje cells indicates that AQP11 is intracellular [2].

Analytical, diagnostic and therapeutic context of AQP11

Immunohistochemistry revealed that AQP11 was localized intracellularly in the proximal tubule [1].

References

Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Morishita, Y., Matsuzaki, T., Hara-chikuma, M., Andoo, A., Shimono, M., Matsuki, A., Kobayashi, K., Ikeda, M., Yamamoto, T., Verkman, A., Kusano, E., Ookawara, S., Takata, K., Sasaki, S., Ishibashi, K. Mol. Cell. Biol. (2005) [Pubmed]
Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. Gorelick, D.A., Praetorius, J., Tsunenari, T., Nielsen, S., Agre, P. BMC Biochem. (2006) [Pubmed]

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