Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TUSC1 - tumor suppressor candidate 1

Homo sapiens

Synonyms: TSG-9, TSG9, Tumor suppressor candidate gene 1 protein

Shan, Z. et al., Yamada, H.Y. et al.

Yamada, Gorbsky,

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Disease relevance of TUSC1

Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer [1].

High impact information on TUSC1

Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 [2].
Analysing cell line cDNAs by reverse transcriptase (RT)-PCR demonstrated downregulation of TUSC1 in cell lines with or without HDs, suggesting that TUSC1 may play a role in lung tumorigenesis [1].
Multiplex polymerase chain reaction and Southern blot confirmed the HD of TUSC1 [1].
Northern blot analysis of TUSC1 demonstrated two transcripts of approximately 2 and 1.5 kb that are likely generated by alternative polyadenylation signals [1].

References

Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. Shan, Z., Parker, T., Wiest, J.S. Oncogene (2004) [Pubmed]
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Yamada, H.Y., Gorbsky, G.J. Oncogene (2006) [Pubmed]

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