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Gene Review

Xbp1  -  X-box binding protein 1

Rattus norvegicus

Synonyms: HTF, Hepatocarcinogenesis-related transcription factor, Htf, X-box-binding protein 1
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Disease relevance of Xbp1


High impact information on Xbp1

  • Transformed cells carrying pmt in the vicinity of the HTF island have a propensity to revert at a relatively high rate of about 2 X 10(-3) per cell per generation by a mechanism probably involving methylation of some CpG sites in the island [2].
  • In vitro culture of young one-cell embryos using common embryo media (KSOM, BMOC, or HTF) for 18-22 h followed by culture in mR1ECM medium allows the successful in vitro development of blastocysts from one-cell embryos after 5 days from both outbred (SD) and inbred strains of rat (WF, LEW, F344, and PVG) [3].
  • We investigated htf gene expression in rat tissues by Northern analysis and found that HTF expression was ubiquitous but was enriched in the liver [4].
  • Consequently, HTF is thought to participate in hepatocyte growth as well as in hepatocarcinogenesis [4].
  • Two hepatotrophic protein factors (HTF) were partially purified from the serum-free conditioned medium of the embryo rat fibroblastic cell line FRL [5].

Biological context of Xbp1

  • HTF induced cell adherence to the culture plate, promoted life maintenance, scattering and enhanced 3H-Thymidine uptake into DNA and cell proliferation in two sensitive murine non-transformed, epithelial hepatocytic cell lines (C6 and C2.8) [5].

Analytical, diagnostic and therapeutic context of Xbp1


  1. Identity between rat htf and human xbp-1 genes: determination of gene structure, target sequence, and transcription promotion function for HTF. Kokura, K., Kishimoto, T., Tamura, T. Gene (2000) [Pubmed]
  2. Effect of CpG-rich sequences in transformation and tumorigenesis by polyomavirus. Renzo, A., Bouchard, L., Mongeau, C.J., Bastin, M. Oncogene (1989) [Pubmed]
  3. Two-phase chemically defined culture system for preimplantation rat embryos. Zhou, Y., Galat, V., Garton, R., Taborn, G., Niwa, K., Iannaccone, P. Genesis (2003) [Pubmed]
  4. Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans. Kishimoto, T., Kokura, K., Ohkawa, N., Makino, Y., Yoshida, M., Hirohashi, S., Niwa, S., Muramatsu, M., Tamura, T. Cell Growth Differ. (1998) [Pubmed]
  5. High molecular weight hepatotrophic factors released in serum-free medium by the cultured embryo rat fibroblastic cell line FRL. Borney, M.F., Dal Monte, M., Chiavacci, L., D'Urso, C.M., Revoltella, R.P. J. Biol. Regul. Homeost. Agents (1993) [Pubmed]
  6. HTF: A b-ZIP transcription factor that is closely related to the human XBP/TREB5 and is activated by hepatocellular carcinoma in rats. Kishimoto, T., Kokura, K., Kumagai, Y., Wakamatsu, T., Makino, Y., Tamura, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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