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Uqcrfs1  -  ubiquinol-cytochrome c reductase, Rieske...

Rattus norvegicus

Synonyms: Complex III subunit 5, Cytochrome b-c1 complex subunit 5, Cytochrome b-c1 complex subunit Rieske, mitochondrial, Liver regeneration-related protein LRRGT00195, RISP, ...
 
 
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High impact information on Uqcrfs1

  • The drugs had no effect on levels of ubiquitously expressed RISP mRNA in fibroblasts [1].
  • Exogenous reactive oxygen species increased the plasma membrane Na,K-ATPase degradation, whereas, in mitochondrial DNA deficient rho(0) cells and in cells transfected with small interfering RNA against Rieske iron sulfur protein, the hypoxia-mediated Na,K-ATPase degradation was prevented [2].
  • Both bypasses are inhibited by myxothiazol, which blocks electron flow from ubiquinol to the Rieske iron-sulfur center, and by 2-hydroxy-3-undecyl-1,4-naphthoquinone, which inhibits electron flow from the iron-sulfur center to cytochrome c1 [3].
 

Analytical, diagnostic and therapeutic context of Uqcrfs1

References

  1. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. Jeyaseelan, R., Poizat, C., Wu, H.Y., Kedes, L. J. Biol. Chem. (1997) [Pubmed]
  2. Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Comellas, A.P., Dada, L.A., Lecuona, E., Pesce, L.M., Chandel, N.S., Quesada, N., Budinger, G.R., Strous, G.J., Ciechanover, A., Sznajder, J.I. Circ. Res. (2006) [Pubmed]
  3. Bypasses of the antimycin a block of mitochondrial electron transport in relation to ubisemiquinone function. Alexandre, A., Lehninger, A.L. Biochim. Biophys. Acta (1984) [Pubmed]
  4. Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex. Nishikimi, M., Hosokawa, Y., Toda, H., Suzuki, H., Ozawa, T. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  5. Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase. Sun, G., Kinter, M.T., Anderson, V.E. Journal of mass spectrometry : JMS. (2003) [Pubmed]
 
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