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Gene Review:

Hax1 - HCLS1 associated protein X-1

Rattus norvegicus

Synonyms: HAX-1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1, HSP1BP-1, ...

Han, Y. et al., Grzybowska, E.A. et al.

Grzybowska, Sarnowska, Konopiński, Wilczyńska, Sarnowski, Siedlecki,

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High impact information on Hs1bp1

Analysis of expression indicates that overall Hax-1 mRNA level is relatively low in most tissues and very high in testes, and that the expression pattern of the variants is similar in different tissues [1].
Hax-1 protein, which has been studied in mice and humans, shows a potent anti-apoptotic activity and is involved in regulation of cell motility [1].
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition [2].
Through a yeast two-hybrid screening of adult human heart cDNA library, we identified HS-1 associated protein-1 (HAX-1), a 35-kD BH-domain containing protein localized to the mitochondria as one of the molecules that interacts with caspase-9 [2].

Biological context of Hs1bp1

Overexpression of HAX-1 in adult cardiac myocytes conferred 30% protection from apoptosis as compared with the control [2].
Suppression of HAX-1 expression using siRNA-HAX-1 resulted in significant cell death in adult cardiac myocytes, suggesting the importance of HAX-1 in cardiac myocyte resistance to apoptotic stimulation [2].

References

Identification and expression analysis of alternative splice variants of the rat Hax-1 gene. Grzybowska, E.A., Sarnowska, E., Konopiński, R., Wilczyńska, A., Sarnowski, T.J., Siedlecki, J.A. Gene (2006) [Pubmed]
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Han, Y., Chen, Y.S., Liu, Z., Bodyak, N., Rigor, D., Bisping, E., Pu, W.T., Kang, P.M. Circ. Res. (2006) [Pubmed]

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