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Gene Review

HAX1  -  HCLS1 associated protein X-1

Homo sapiens

Synonyms: HAX-1, HCLS1-associated protein X-1, HCLSBP1, HS1-associating protein X-1, HS1-binding protein 1, ...
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Disease relevance of HAX1


High impact information on HAX1


Biological context of HAX1


Anatomical context of HAX1


Associations of HAX1 with chemical compounds

  • HAX-1 was first identified as a protein that associates with HS1, a target of non-receptor protein tyrosine kinases within haematopoietic cells [7].

Physical interactions of HAX1

  • The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1 [10].

Other interactions of HAX1

  • During studies aimed at understanding the function of the N-terminal peptide of interleukin-1 alpha (IL-1 NTP, amino acids 1-112), which is liberated from the remainder of IL-1 alpha during intracellular processing, we identified by yeast two-hybrid analysis a putative interacting protein previously designated as HAX-1 [7].
  • In contrast, two anti-apoptotic genes, hurpin and HAX-1, were downregulated [11].

Analytical, diagnostic and therapeutic context of HAX1


  1. HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Klein, C., Grudzien, M., Appaswamy, G., Germeshausen, M., Sandrock, I., Sch??ffer, A.A., Rathinam, C., Boztug, K., Schwinzer, B., Rezaei, N., Bohn, G., Melin, M., Carlsson, G., Fadeel, B., Dahl, N., Palmblad, J., Henter, J.I., Zeidler, C., Grimbacher, B., Welte, K. Nat. Genet. (2007) [Pubmed]
  2. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. Suzuki, Y., Demoliere, C., Kitamura, D., Takeshita, H., Deuschle, U., Watanabe, T. J. Immunol. (1997) [Pubmed]
  3. K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. Sharp, T.V., Wang, H.W., Koumi, A., Hollyman, D., Endo, Y., Ye, H., Du, M.Q., Boshoff, C. J. Virol. (2002) [Pubmed]
  4. HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis. Mirmohammadsadegh, A., Tartler, U., Michel, G., Baer, A., Walz, M., Wolf, R., Ruzicka, T., Hengge, U.R. J. Invest. Dermatol. (2003) [Pubmed]
  5. Intracellular IL-1{alpha}-binding proteins contribute to biological functions of endogenous IL-1{alpha} in systemic sclerosis fibroblasts. Kawaguchi, Y., Nishimagi, E., Tochimoto, A., Kawamoto, M., Katsumata, Y., Soejima, M., Kanno, T., Kamatani, N., Hara, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz, D.F., Moseley, J., Calderon, G., Swift, A.L., Li, S., Arias, I.M. J. Biol. Chem. (2004) [Pubmed]
  7. Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein. Yin, H., Morioka, H., Towle, C.A., Vidal, M., Watanabe, T., Weissbach, L. Cytokine (2001) [Pubmed]
  8. Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1. Yedavalli, V.S., Shih, H.M., Chiang, Y.P., Lu, C.Y., Chang, L.Y., Chen, M.Y., Chuang, C.Y., Dayton, A.I., Jeang, K.T., Huang, L.M. J. Virol. (2005) [Pubmed]
  9. Expression and tissue distribution of mouse Hax1. Hippe, A., Bylaite, M., Chen, M., von Mikecz, A., Wolf, R., Ruzicka, T., Walz, M. Gene (2006) [Pubmed]
  10. The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1. Al-Maghrebi, M., Brulé, H., Padkina, M., Allen, C., Holmes, W.M., Zehner, Z.E. Nucleic Acids Res. (2002) [Pubmed]
  11. Gene expression in actinic keratoses: pharmacological modulation by imiquimod. Lysa, B., Tartler, U., Wolf, R., Arenberger, P., Benninghoff, B., Ruzicka, T., Hengge, U.R., Walz, M. Br. J. Dermatol. (2004) [Pubmed]
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