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Gene Review

Hax1  -  HCLS1 associated X-1

Mus musculus

Synonyms: HAX-1, HCLS1-associated protein X-1, HS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1, ...
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Disease relevance of Hax1


High impact information on Hax1


Biological context of Hax1

  • Overexpression of HAX-1 in adult cardiac myocytes conferred 30% protection from apoptosis as compared with the control [3].
  • HAX-1 represses postmitochondrial caspase-9 activation and cell death during hypoxia-reoxygenation [4].
  • Through a yeast two-hybrid screening of adult human heart cDNA library, we identified HS-1 associated protein-1 (HAX-1), a 35-kD BH-domain containing protein localized to the mitochondria as one of the molecules that interacts with caspase-9 [3].

Anatomical context of Hax1


Analytical, diagnostic and therapeutic context of Hax1


  1. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. Radhika, V., Onesime, D., Ha, J.H., Dhanasekaran, N. J. Biol. Chem. (2004) [Pubmed]
  2. Expression and tissue distribution of mouse Hax1. Hippe, A., Bylaite, M., Chen, M., von Mikecz, A., Wolf, R., Ruzicka, T., Walz, M. Gene (2006) [Pubmed]
  3. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Han, Y., Chen, Y.S., Liu, Z., Bodyak, N., Rigor, D., Bisping, E., Pu, W.T., Kang, P.M. Circ. Res. (2006) [Pubmed]
  4. HAX-1 represses postmitochondrial caspase-9 activation and cell death during hypoxia-reoxygenation. Shaw, J., Kirshenbaum, L.A. Circ. Res. (2006) [Pubmed]
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