Disease relevance of Hax1

• These findings, along with the observation that Hax-1 is overexpressed in metastatic tumors and tumor cell lines, suggest a novel role for the association of oncogenic Galpha13 and Hax-1 in tumor metastasis [1].

High impact information on Hax1

• Expression of Hax-1 reduces the formation of actin stress fibers and focal adhesion complexes in Galpha13-expressing NIH3T3 cells [1].
• Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1 [1].
• The results presented here summarize for the first time the expression of the murine Hax1 in different tissues and two cell lines [2].
• We found Hax1 to be localised mainly in the cytoplasm and detected a partial colocalisation with mitochondria [2].
• Expression and tissue distribution of mouse Hax1 [2].

Biological context of Hax1

• Overexpression of HAX-1 in adult cardiac myocytes conferred 30% protection from apoptosis as compared with the control [3].
• HAX-1 represses postmitochondrial caspase-9 activation and cell death during hypoxia-reoxygenation [4].
• Through a yeast two-hybrid screening of adult human heart cDNA library, we identified HS-1 associated protein-1 (HAX-1), a 35-kD BH-domain containing protein localized to the mitochondria as one of the molecules that interacts with caspase-9 [3].

Anatomical context of Hax1

• At the RNA level, we found the highest expression of Hax1 in liver, kidney and testis [2].
• Interestingly, the most prominent expression of Hax1 was found in epithelial, endothelial and muscle cells [2].
• Furthermore, we have studied the subcellular localisation of Hax1 in a keratinocyte and a neuronal cell line by immunofluorescence [2].

Analytical, diagnostic and therapeutic context of Hax1

• Furthermore, the distribution of Hax1 within different mouse tissues was studied by immunohistochemistry (IHC) [2].

References